Table of Contents
ISRN Anesthesiology
Volume 2013, Article ID 103289, 6 pages
http://dx.doi.org/10.1155/2013/103289
Clinical Study

Pharmacoeconomics and Pharmacodynamic Interactions of Rocuronium and Pancuronium

1Department of Anesthesiology and Intensive Care, Narayana Hrudayalaya Malla Reddy Hospital, No. 1-1-216, Suraram “X” Road, Jeedimetla, Hyderabad 500055, India
2Department of Anesthesiology and Intensive Care, Nizam’s Institute of Medical Sciences, Panjagutta, Hyderabad 500082, India
3Departments of Clinical Pharmacology and Medical Research, Narayana Medical College and Super Specialty Hospital, Chinthareddypalem, Nellore 524002, Andhra Pradesh, India
4Department of Clinical Pharmacology, Narayana Medical College and Super Specialty Hospital, Chinthareddypalem, Nellore 524002, Andhra Pradesh, India
5Department of Anesthesiology and Intensive Care, Narayana Medical College and Super Specialty Hospital, Chinthareddypalem, Nellore 524002, Andhra Pradesh, India

Received 17 December 2012; Accepted 3 January 2013

Academic Editors: E. Freye and C. H. Wong

Copyright © 2013 HariSrinivas Shyam Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We evaluated the pharmacodynamic interaction of the combination of pancuronium and Rocuronium by analyzing time-response relationship, quality of intubating conditions, changes in the hemodynamics, and cost effectiveness as compared to individual drugs. Methods. Sixty patients in the ASA-I category received either 10 ml of 0.9 mg/kg rocuronium (R) plus 10 ml of saline or 10 ml of 0.1 mg/kg pancuronium (P) plus 10 ml of saline or a combination (C) of 10 ml of 0.45 mg/kg R plus 10 ml of 0.05 mg/kg P according to randomization list. Neuromuscular function was measured up to maximal suppression of twitch height. Results. The mean times (sec) taken for twitch height to decrease to 50% of baseline in R, P, and C were , , and , respectively. The mean cost of intubation per patient was INR in group R, INR in group P, and INR in group C. Conclusions. The combination of P and R provides rapid and smooth intubation with minimal hemodynamic changes at a reasonably priced cost.