Sulfonamide Based β-Carbonic Anhydrase Inhibitors: 2D QSAR Study

Table 3

Structure and β-CAs inhibitory activity of ureido-substituted benzenesulfonamides derivatives.

Comp. no.	R	Activity in pK𝑖
u01	–(sulfanilamide)	−0.035
u02	Ph	0.403
u03	PhCH2	0.262
u04	Ph2CH	−0.598
u05	4-FC6H4	1.375
u06	4-ClC6H4	1.207
u07	4-BrC6H4	1.346
u08	4-IC6H4	1.371
u09	4-CF3C6H4	1.214
u10	3,5-CF3C6H4	1.232
u11	2,3,4,5,6-FC6H4	1.420
u12	2-OCH3C6H4	0.153
u13	4-CH3CO-C6H4	1.536
u14	2-isopropyl-C6H4	−0.537
u15	4-isopropyl-C6H4	0.449
u16	4-n-butyl-C6H4	1.301
u17	4-oxybutyl-C6H4	1.295
u18	4-n-octyl-C6H4	1.338
u19	4-NCC6H4	1.271
u20	2-NCC6H4	0.486
u21	4-PhOC6H4	2.468
u22	2-PhC6H4	0.527
u23	3-O2NC6H4	1.396
u24	4-MeO-2-MeC6H3	1.274
u25	9H-Fluoren-2-yl	0.241
u26	Cyclopentyl	0.247
u27	3,5-Me2C6H3	1.181
u28	Indan-5-yl	1.143