Table of Contents
ISRN Neurology
Volume 2013, Article ID 134858, 17 pages
Review Article

The Afferent Visual Pathway: Designing a Structural-Functional Paradigm of Multiple Sclerosis

Departments of Clinical Neurosciences and Surgery (Ophthalmology), Hotchkiss Brain Institute, University of Calgary, Canada

Received 14 May 2013; Accepted 11 July 2013

Academic Editors: B. Drukarch, A. Martinuzzi, Y. Ohyagi, A. K. Petridis, D. Schiffer, and S. Tobimatsu

Copyright © 2013 Fiona Costello. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple sclerosis (MS) is a disease of the central nervous system (CNS) believed to arise from a dysfunctional immune-mediated response in a genetically susceptible host. The actual cause of MS is not known, and there is ongoing debate about whether this CNS disorder is predominantly an inflammatory versus a degenerative condition. The afferent visual pathway (AVP) is frequently involved in MS, such that one in every five individuals affected presents with acute optic neuritis (ON). As a functionally eloquent system, the AVP is amenable to interrogation with highly reliable and reproducible tests that can be used to define a structural-functional paradigm of CNS injury. The AVP has numerous unique advantages as a clinical model of MS. In this review, the parameters and merits of the AVP model are highlighted. Moreover, the roles the AVP model may play in elucidating mechanisms of brain injury and repair in MS are described.