Integrin Signaling as a Cancer Drug Target

Table 2

Transgenic mouse models: FAK.

Model	Cancer type	Effect on tumor growth	Effect on metastasis	Reference
FAK^fl/fl; MMTV-Cre; PyMT	Breast cancer	Delayed initiation; decreased growth	Decreased lung metastasis	[117]
FAK^fl/fl; MMTV-Cre; PyMT	Breast cancer	Reduced tumor cell proliferation	Blocked progression from hyperplasia to carcinoma; blocked metastasis	[118]
FAK^fl/fl; MMTV-Cre; PyMT	Breast cancer	Reduced initiation; reduced proliferation; reduced cancer stem/progenitor cell population	Not studied	[119]
FAK^fl/fl; MMTV-Cre; PyMT	Breast cancer	Reduced initiation; reduced proliferation; increased apoptosis	Decreased progression from hyperplasia to carcinoma	[120]
FAK^fl/fl; K14-CreERT2; two-stage chemical carcinogenesis protocol	Skin cancer	Reduced initiation; reduced growth; increased apoptosis	Reduced progression from papilloma to squamous cell carcinoma	[121]