Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil

Table 1

(a) Composition of gastroretentive floating tablets of Atenolol prepared using hydrophobic retardant (HCSO) (F1 to F4). (b) Composition of gastroretentive floating tablets of Atenolol prepared using hydrophilic polymer (HPMC K4M) (F5 to F8). (c) Composition of gastroretentive floating tablets of Atenolol prepared using hydrophilic polymer (HPMC K15M) (F9 to F12). (d) Composition of gastroretentive floating tablets of Atenolol prepared using hydrophilic-hydrophobic combination (F13 to F18).

(a)

S. No	Ingredients	F1	F2	F3	F4
1	Atenolol	50	50	50	50
2	Hydrogenated cottonseed oil	50	100	150	175
3	Sodium bicarbonate	45	45	45	45
4	Avicel	152	102	52	27
5	Magnesium stearate	3	3	3	3

(b)

S. No	Ingredients	F5	F6	F7	F8
1	Atenolol	50	50	50	50
2	HPMC K4M	50	100	150	175
3	Sodium bicarbonate	45	45	45	45
4	Avicel	152	102	52	27
5	Magnesium stearate	3	3	3	3

(c)

S. No	Ingredients	F9	F10	F11	F12
1	Atenolol	50	50	50	50
2	HPMC K15M	50	100	150	175
3	Sodium bicarbonate	45	45	45	45
4	Avicel	152	102	52	27
5	Magnesium stearate	3	3	3	3

(d)

S. No	Ingredients	F13	F14	F15	F16	F17	F18
1	Atenolol	50	50	50	50	50	50
2	Hydrogenated cottonseed oil	16.67	33.33	50	25	70	15
3	HPMC K4M	16.67	33.33	25	50	15	70
4	HPMC K15M	16.67	33.33	25	25	15	15
5	Sodium bicarbonate	45	45	45	45	45	45
6	Avicel	152	102	102	102	102	102
7	Magnesium stearate	3	3	3	3	3	3