Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil

Table 7

The in vitro drug release profiles for the formulations (F9–F18).

Time (hrs)	F9	F10	F11	F12	F15	F16	F17	F18
0	0	0	0	0	0	0	0	0
1	26.34±0.78	23.34±0.96	22.35±0.98	22.78±0.99	23.34±0.78	22.45±0.90	24.34±0.67	22.66±0.88
2	34.27±1.25	36.23±0.67	33.71±0.78	31.41±0.78	38±0.46	36.74±0.67	31.56±0.54	27.89±0.97
3	42.59±0.90	42.19±0.89	36.72±1.02	35.8±0.60	49.04±0.78	44.82±0.78	41.51±0.78	35.81±0.67
4	51.04±0.56	50.83±0.67	43.53±0.67	43.31±0.66	57.2±0.98	51.13±0.65	51.08±1.34	39.45±0.45
5	56.6±0.89	58.22±0.78	46.29±0.69	45.39±0.56	63.3±0.67	62.9±0.67	57.29±1.55	46.78±0.33
6	63.82±1.33	63.37±1.23	49±0.77	47.44±0.88	67.06±0.56	63.36±0.55	60.5±0.78	53.98±0.78
7	67.44±0.56	64.8±0.78	51.58±0.66	53.18±0.73	74.96±0.77	75.08±0.77	65.83±0.56	59.34±0.66
8	70.89±0.34	66.99±1.45	56.52±0.45	55.55±0.67	85.18±0.55	81.15±0.44	77.82±0.55	64.67±0.34
9	76.38±0.45	72.58±0.78	61.84±0.79	59.05±1.67	92.36±0.78	87.63±0.78	81.32±0.88	70.56±0.78
10	81.49±0.68	79.16±0.60	68.24±0.66	62.97±0.78	96.94±0.55	94.53±0.87	88.61±0.98	74.33±0.67
11	86.5±0.56	82.82±0.78	72.31±0.56	69.58±0.23	99.49±0.67	98.91±0.98	95.95±1.56	80.22±0.65
12	93.96±0.95	85.57±0.85	76.59±0.77	72.18±0.56	—	—	99.08±0.88	86.78±0.73

∗All above reading are average ± SD, 𝑛=6.