Traveled Distance Is a Sensitive and Accurate Marker of Motor Dysfunction in a Mouse Model of Multiple Sclerosis

Figure 1

EAE progression.

(a) The time course of EAE scores in WT EAE mice (𝑛=5) after MOG_35--55 immunization. The data are shown as the mean clinical EAE scores ± s.e.

(b) Temporal changes in the open-field tests of the same WT EAE mice. The data are shown as the traveled distances at day 0 (prior to EAE induction) and at days 7, 10, and 14 after the immunization of the EAE mice (*𝑃<0.05)

(c) Temporal changes in the open-field tests of WT naïve mice and WT EAE mice. The data are shown as the traveled distances at day 0 (prior to EAE induction) and at days 7, 10, and 14 after the immunization of the EAE mice (closed squares, 𝑛=5) and normal conditions for naïve control mice (open circles, 𝑛=6) (*𝑃<0.05)