Table of Contents
ISRN Radiology
Volume 2013, Article ID 174524, 5 pages
Research Article

Comparison of Hippocampal Volume in Dementia Subtypes

1Department of Radiology, Banaras Hindu University, Uttar Pradesh, India
2Department of General Surgery, Victoria Hospital Bangalore Medical College and Research Institute, No. 128 Vijay Doctors Colony, Konanakunte, Bangalore 560062, Karnataka, India

Received 10 October 2012; Accepted 5 November 2012

Academic Editors: E. J. van Beek and Y. Yang

Copyright © 2013 Avinash Vijayakumar and Abhishek Vijayakumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. To examine the relationship between different types of dementia and hippocampal volume. Methods. Hippocampal volume was measured using FL3D sequence magnetic resonance imaging in 26 Alzheimer's, vascular dementia, mixed dementia, and normal pressure hydrocephalus patients and 15 healthy controls and also hippocampal ratio, analyzed. Minimental scale was used to stratify patients on cognitive function impairments. Results. Hippocampal volume and ratio was reduced by 25% in Alzheimer’s disease, 21% in mixed dementia, 11% in vascular dementia and 5% in normal pressure hydrocephalus in comparison to control. Also an asymmetrical decrease in volume of left hippocampus was noted. The severity of dementia increased in accordance to decreasing hippocampal volume. Conclusion. Measurement in hippocampal volume may facilitate in differentiating different types of dementia and in disease progression. There was a correlation between hippocampal volume and severity of cognitive impairment.