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ISRN Biochemistry
Volume 2013 (2013), Article ID 182601, 6 pages
Research Article

Serum Prolidase Activity, Oxidant and Antioxidant Status in Nonulcer Dyspepsia and Healthy Volunteers

1Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
2Department of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India
3Department of Biochemistry, School of Life Sciences, Dr. B. R. Ambedkar University, Agra 282002, India

Received 16 July 2013; Accepted 10 September 2013

Academic Editors: H. Inoue, A. Jiménez, A.-M. Lambeir, F. May, and B. Penke

Copyright © 2013 Shweta Kumari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Helicobacter pylori (H. pylori) infection is associated with increased oxidative stress and serum prolidase activity (SPA) in many diseases. We aimed to observe SPA and oxidative stress in nonulcer dyspepsia (NUD) infected with and without H. pylori among eastern Indians. 106 patients with H. pylori positive NUD, 82 patients with H. pylori negative NUD, and 50 healthy individuals were selected. SPA, total antioxidant capacity (TAOC), and total oxidant status (TOS) were measured with the use of spectrophotometer and an automated measurement method. SPA, TOS, and oxidative stress index (OSI) were significantly higher in patients with H. pylori positive than H. pylori negative NUD and healthy individuals (all ), whereas TAOC was significantly lower ( ). Nonsignificant, increased SPA ( value = 0.6083) and decreased TAOC ( value = 0.1186) were observed in patients with H. pylori negative NUD than healthy individuals, while increased TOS and OSI were significant ( ). Weak, nonsignificant correlations were observed between serum prolidase activity and TAOC, TOS, and OSI in H. pylori positive cases. Thus, increased SPA along with increased oxidative stress was observed, which seem to be closely associated with H. pylori infection. SPA and oxidative stress seem to be used as biomarkers for H. pylori infection in NUD.