Functional Interactions in Transcription and Splicing of Ewing’s Sarcoma

Figure 2

Schematic model of the link between transcription complex and spliceosome, reflecting interaction partners of EWS and EFPs. EWS is a bridge between components of basal transcriptional machinery and splicing apparatus of the general gene expression. EWS protein interacts via its RBD with nuclear ribonucleoproteins (hnRNPs) and RNA helicases. Shown are participants in transcription and splicing: EFP, hnRNPs, RPB7, EWS, YB-1, hnRNPs, RNA helicases, and other binding functional proteins. EWS could be divided into SYGQ-rich TAD and C-terminal RBD. This model shows to which regions of EWS and EFPs the interaction partners preferentially bind. Some interactions are depicted by arrows to better represent the unknown composition and possible flexibility of EWS and EFP containing complexes.