Table of Contents
ISRN Vascular Medicine
Volume 2013, Article ID 186759, 5 pages
Clinical Study

Acute Effects of Two Angiotensin Receptor Blockers on Vascular Hemodynamics, Arterial Stiffness, and Oxidative Stress in Patients with Mild to Moderate Hypertension: An Open Label Parallel Group Study

1Narayana Medical College and Hospital, Chinthareddypalem, Nellore, Andhra Pradesh 524002, India
2Nizams Institute of Medical Sciences, Panjagutta, Hyderabad, Andhra Pradesh 500082, India

Received 1 November 2012; Accepted 9 December 2012

Academic Editors: A. Mugge and P. Schoenhagen

Copyright © 2013 Rama Mohan Pathapati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. We studied the acute effects of Olmesartan and Telmisartan at baseline and at the end of four weeks on indices of hemodynamics (heart rate HR, blood pressure BP), vascular (carotid femoral pulse wave velocity cf PWV, digital arterial tone expressed as Reflection index RI, and endothelial dependent vasodilator response EDVR), and oxidative stress (serum Malondialdehyde MDA) in hypertensive patients. Materials and Methods. The eligible patients were randomly allocated to either 20 mg Olmesartan or 40 mg Telmisartan. Results. 40 subjects received Olmesartan, and 29 received Telmisartan. After four weeks of treatment the mean changes from baseline in the Olmesartan group versus Telmisartan group are SBP versus  mm Hg, ; DBP versus  mm Hg, ; cf PWV versus  m/s, ; EDVR versus %, ; and MDA versus ηMol/mL, . Conclusion. Olmesartan showed a better improvement in cf PWV, EDVR, and MDA than Telmisartan with an identical reduction in blood pressure.