Table of Contents
ISRN Dentistry
Volume 2013, Article ID 195678, 9 pages
Clinical Study

The Role of Interleukin-1 Genotype in the Association between Coronary Heart Disease and Periodontitis in a Syrian Population

1Department of Periodontology, Faculty of Dentistry, Damascus University, Al-Mezzeh, Damascus, Syria
2Department of Microbiology and Genetics, Faculty of Medicine, Damascus University, Damascus, Syria

Received 15 February 2013; Accepted 17 March 2013

Academic Editors: D. Drake and J. H. Jeng

Copyright © 2013 Lina Bashour et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To determine whether differences exist between periodontitis subjects with and without Coronary Heart Disease (CHD) in a Syrian population in the distribution of IL-1 alleles at positions IL-1 +4845, IL-1 +3954, IL-1 −511, and IL-1RN VNTR. Background. The role of Interleukin-1 genes in the association between periodontitis and CHD has been demonstrated in previous studies. No study has been carried out on the Syrian population to asses for such a role. Methods. 200 Syrian Arab periodontitis patients (184 males, 16 females; mean age 52.61) were divided into two groups: cases group 100 subjects with CHD (92 males, 8 females; mean age 52.06); controls group 100 subjects without CHD (92 males, 8 females; mean age 53.16). Probing depth (PD), clinical attachment loss (CAL), and alveolar bone loss (ABL) were performed for patients. Blood samples were collected for genotyping analysis of IL-1 +4845, IL-1 +3954, and IL-1 −511 using PCR-RFLP technique and IL-1RN VNTR using normal PCR. Results. An association between both (CAL and ABL) and CHD was shown after adjustment for other confounders (OR: 7.659, ; OR: 3.645, , resp.). Also, an association between allele 2 of IL-1 +4845, IL-1 +3954, and IL-1 −511 and ABL was shown. Allele 2 of IL-1 +4845 and IL-1 −511 was associated with ABL among individuals with and without CHD. But after adjustment for other confounders, the association remained only between allele 2 of IL-11 +4845 and both CHD and severe ABL (OR: 0.189, ). Conclusion. Allele 2 of IL-11 +4845 may be considered a risk indicator for having both CHD and severe ABL in the investigated Syrian population.