Clinical Study
The Role of Interleukin-1 Genotype in the Association between Coronary Heart Disease and Periodontitis in a Syrian Population
Table 5
IL-1 genotypes of subjects with and without CHD by varying degrees of ABL.
| | Alveolar bone loss | | Genotype frequency | Mild | Moderate | Severe | P value | | | % | | % | | % | |
| IL-1α +4845 | | | | | | | | CHD | | | | | | | | 1.1 | 7 | 88% | 31 | 78% | 26 | 50% | 0.009 | Combination 1.2 + 2.2 | 1 | 12% | 9 | 22% | 26 | 50% | Non-CHD | | | | | | | | 1.1 | 12 | 100% | 18 | 32% | 7 | 22% | <0.001 | Combination 1.2 + 2.2 | 0 | 0% | 38 | 68% | 25 | 78% | IL-1 +3954 | | | | | | | | CHD | | | | | | | | 1.1 | 5 | 63% | 27 | 68% | 23 | 44% | 0.070 | Combination 1.2 + 2.2 | 3 | 37% | 13 | 32% | 29 | 56% | Non-CHD | | | | | | | | 1.1 | 9 | 75% | 30 | 54% | 13 | 41% | 0.133 | Combination 1.2 + 2.2 | 3 | 25% | 26 | 46% | 19 | 59% | IL-1 −511 | | | | | | | | CHD | | | | | | | | 1.1 | 5 | 63% | 9 | 23% | 29 | 56% | 0.003 | Combination 1.2 + 2.2 | 3 | 37% | 31 | 77% | 23 | 44% | Non-CHD | | | | | | | | 1.1 | 8 | 33% | 32 | 29% | 40 | 63% | <0.001 | Combination 1.2 + 2.2 | 16 | 67% | 80 | 71% | 24 | 37% | IL-1 RA VNTR | | | | | | | | CHD | | | | | | | | 1.1 | 5 | 63% | 14 | 35% | 27 | 52% | 0.107 | Combination 1.2 + 2.2 | 3 | 37% | 26 | 65% | 25 | 48% | Non-CHD | | | | | | | | 1.1 | 4 | 33% | 30 | 54% | 23 | 72% | 0.054 | Combination 1.2 + 2.2 | 8 | 67% | 26 | 46% | 9 | 28% |
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