The Role of 39 Psoriasis Risk Variants on Age of Psoriasis Onset

Table 1

Meta-analysis of associations between 39 selected SNPs and psoriasis age of onset in three case cohorts.^a

Nearby gene	Rs_id	Risk allele of psoriasis/effect allele of age onset	𝑃_GAIN	𝑃_WashU/UCSF	𝑃_UCSF	Beta for effect allele of age onset	𝑃_heterogeneity	Meta-𝑃 value	FDR_𝑞 value	𝑃_NPF
HLA-C	HLA-Cw6	—	4.30𝐸-14	0.0005	3.61𝐸-05	−0.618	0.73	5.28𝐸-21	—	—
HLA-C	rs10484554	T/T	2.22𝐸-11	0.0167	0.000016	−0.380	0.39	1.87𝐸-16	<0.0001	—
HLA-C	rs12191877	T/T	2.79𝐸-11	0.0174	0.000018	−0.372	0.39	2.77𝐸-16	<0.0001	—
IFIH1	rs17716942	T/T	0.0014	0.0668	0.464	−0.201	0.09	0.002	0.028	0.94
HLA-C	rs13191343	T/T	0.0025	0.9000	−1	−0.188	0.22	0.006	0.054	—
LCE3B-LCE3C	rs4112788	G/G	0.0074	0.8299	0.8248	−0.099	0.37	0.021	0.166	—
FBXL19	rs10782001	G/A	0.0366	0.9682	−1	−0.085	0.37	0.059	0.37	—
SDC4	rs1008953	C/C	0.1876	0.1478	−1	0.104	0.47	0.069	0.37	—
FBXL19	rs12924903	A/G	0.0574	0.8552	−1	−0.074	0.34	0.099	0.37	—
TRAF3IP2	rs240993	T/C	0.0659	0.9254	−1	−0.077	0.40	0.102	0.37	—
IL23R	rs11209026	G/G	0.3062	0.6284	0.1364	−0.163	0.65	0.104	0.37	—
IL12B	rs2546890	A/G	0.0630	0.8726	−1	0.074	0.36	0.104	0.37	—
IL12B	rs12188300	T/T	0.0562	0.5824	−1	−0.110	0.20	0.126	0.409	—
IL12B	rs6887695	G/G	0.1230	0.9613	0.7326	0.065	0.79	0.155	0.466	—
IL23R	rs1004819	—/A	0.3657	0.3654	−1	−0.059	0.66	0.230	0.641	—
IL12B	rs953861	G/A	0.1777	0.8474	−1	0.061	0.45	0.258	0.672	—
RPS26	rs12580100	A/G	−1	0.3151	−1	0.164	−1	0.315	0.768	—
TRAF3IP2	rs13210247	G/G	0.6319	0.0106	−1	−0.052	0.01	0.480	0.985	—
IL28RA	rs4649203	A/A	0.4429	0.9925	−1	−0.039	0.73	0.493	0.985	—
NFKBIA	rs8016947	G/G	0.2424	0.1851	−1	−0.026	0.09	0.572	0.985	—
TRAF3IP2	rs33980500	T/T	0.5199	0.0131	−1	−0.045	0.01	0.573	0.985	—
IL12B	rs3212227	T/G	0.7046	0.7332	0.8764	0.030	0.99	0.606	0.985	—
RNF114	rs2235617	C/G	0.9922	0.9954	0.2331	−0.019	0.55	0.640	0.985	—
IL12B	rs3213094	C/T	0.7599	0.7216	0.8764	0.026	0.98	0.644	0.985	—
REL	rs702873	C/T	0.5496	0.8308	−1	−0.019	0.65	0.658	0.985	—
TRAF3IP2	rs458017	C/C	0.2933	0.0073	−1	−0.034	0.004	0.662	0.985	—
IL23A	rs2066808	A/G	0.3600	0.2295	0.0512	0.040	0.05	0.680	0.985	—
TNIP1	rs1024995	C/C	0.7206	0.1018	−1	−0.027	0.10	0.690	0.985	—
TRAF3IP2	rs13190932	A/A	0.4434	0.0415	−1	−0.021	0.03	0.791	0.985	—
None	rs6809854	G/G	0.6310	0.0975	−1	0.014	0.09	0.794	0.985	—
TRAF3IP2	rs13196377	A/G	0.3915	0.0396	−1	0.019	0.03	0.812	0.985	—
NOS2	rs4795067	G/G	0.7816	0.2546	−1	−0.009	0.25	0.844	0.985	—
RNF114	rs495337	G/A	0.8424	0.9978	−1	0.008	0.93	0.856	0.985	—
IL13	rs20541	G/G	0.7918	0.8979	0.962	0.010	0.97	0.857	0.985	—
NFKBIA	rs12586317	T/C	0.7487	0.7428	−1	0.008	0.67	0.878	0.985	—
ERAP1	rs27524	A/G	0.8240	0.8969	−1	0.007	0.83	0.884	0.985	—
TYK2	rs280519	A/G	0.5867	0.2155	−1	0.004	0.18	0.939	0.992	—
TNIP1	rs17728338	A/A	0.7805	0.6041	0.7386	−0.005	0.80	0.942	0.992	—
TNFAIP3	rs610604	G/T	0.8997	0.9178	0.7863	−0.002	0.95	0.967	0.992	—
TYK2	rs12720356	A/C	0.7275	0.5667	−1	0.001	0.50	0.992	0.992	—

FDR_𝑞: false discovery rate adjusted 𝑃 value based on 39 selected SNPs. aIn total, 898, 182, 418, and 489 psoriasis cases were included in the GAIN, WashU/UCSF, UCSF, and NPF case cohorts, respectively; for certain SNPs that were imputed with low confidence (proper_info < 0.5 for rs12580100) in GAIN cohort or were not genotyped in UCSF case cohort, their information (denoted as 𝑃 = “−1”) was not included in the corresponding meta-analysis; Cochran's 𝑄 statistic was used to examine the heterogeneity.