Research Article
Analysis of CYP2D6 Allele Frequencies and Identification of Novel SNPs and Sequence Variations in Sardinians
Table 5
CYP2D6 allele frequencies in 250 healthy Sardinian people.
| | Variant allele | Number of chromosomes | Frequency
(%) | Correlated enzymatic activity [5] |
| |
*
1A | 148 | 29.6 | EM | |
*
1B | 5 | 1.0 | EM | |
*
1D | 4 | 0.8 | EM | |
*
2A | 75 | 15.0 | EM | |
*
2L | 11 | 2.2 | EM | |
*
2M | 8 | 1.6 | EM | | SH3 | 7 | 1.4 | Not known | | SH4 | 1 | 0.2 | Not known | |
*
3B | 11 | 2.2 | PM | |
*
4A | 84 | 16.8 | PM | |
*
5 | 5 | 1.0 | PM | |
*
6A | 1 | 0.2 | PM | |
*
9 | 1 | 0.2 | IM | |
*
10B | 27 | 5.4 | IM | |
*
15 | 3 | 0.6 | PM | |
*
20 | 1 | 0.2 | PM | |
*
28 | 4 | 0.8 | Not known | |
*
35A | 5 | 1.0 | EM | |
*
41 | 46 | 9.2 | IM | | SH1 | 41 | 8.2 | Not known | | SH2 | 2 | 0.4 | Not known | |
*
1 × N | 4 | 0.8 | UM | |
*
2 × N | 6 | 1.2 | UM |
|
|
Total chromosomes number = 500. SH1: Sardinian haplotype 1; SH2: Sardinian haplotype 2; SH3: Sardinian haplotype 3; SH4: Sardinian haplotype 4.
|
