Analysis of CYP2D6 Allele Frequencies and Identification of Novel SNPs and Sequence Variations in Sardinians

Table 5

CYP2D6 allele frequencies in 250 healthy Sardinian people.


Variant allele	Number of chromosomes	Frequency (%)	Correlated enzymatic activity [5]

* 1A	148	29.6	EM
* 1B	5	1.0	EM
* 1D	4	0.8	EM
* 2A	75	15.0	EM
* 2L	11	2.2	EM
* 2M	8	1.6	EM
SH3	7	1.4	Not known
SH4	1	0.2	Not known
* 3B	11	2.2	PM
* 4A	84	16.8	PM
* 5	5	1.0	PM
* 6A	1	0.2	PM
* 9	1	0.2	IM
* *10B*	27	5.4	IM
* 15	3	0.6	PM
* 20	1	0.2	PM
* 28	4	0.8	Not known
* *35A*	5	1.0	EM
* 41	46	9.2	IM
SH1	41	8.2	Not known
SH2	2	0.4	Not known
* *1 × N*	4	0.8	UM
* *2 × N*	6	1.2	UM

Total chromosomes number = 500. SH1: Sardinian haplotype 1; SH2: Sardinian haplotype 2; SH3: Sardinian haplotype 3; SH4: Sardinian haplotype 4.