International Scholarly Research Notices / 2013 / Article / Tab 6

Research Article

Analysis of CYP2D6 Allele Frequencies and Identification of Novel SNPs and Sequence Variations in Sardinians

Table 6

CYP2D6 allele frequencies detected in 250 healthy Sardinian people and previous frequencies found in reference populations. In these results, “Sardinian haplotypes 1” and “2” are considered as part of CYP2D6*41 allele, instead “Sardinian haplotypes 3 and 4” are considered as part of CYP2D6*2 allele.

Variant alleleSardinian frequencies (%)
( )
Sardinian frequencies (%)
( ) [11]
Sardinian frequencies (%)
( ) [12]
Mediterranean frequencies (%)
( ) [12]
German frequencies (%)
( ) [18]
White subjects frequencies (%)
( ) [23]
European frequencies (%)
( ) [24, 25]
Caucasian frequencies (%) [26]Correlated enzymatic activity [5]

* 1 31.428.636.540.8ª36.436.433.4ndEM
* 2 20.435.740.637.1ª32.417.532.9ndEM
* 3 2.21.83.11.52.0nd1.8ndPM
* 4 16.821.412.516.0ª20.7nd18.912–21PM
* 5 1.01.81.0nd2.0nd7.34–6PM
* 6 0.20.80.9nd1.4ndPM
* 9 0.20.61.82.12.6ndIM
* 10 5.45.44.22.91.51.81.41-2IM
* 15 0.6ndndnd0.1ndndndPM
* 20 0.2ndndndndndndndPM
* 28 0.8ndndndndndndndNot known
* 35 1.0ndndndnd5.2ndndEM
* 41 17.83.6ndndnd8.4ndndIM
* 1 N 0.8nd0.5ndndUM
* 2 N 1.21.82.1nd1.31.1nd1–5UM

—: allele not found in the study; nd: allele not detected in reference study; aincluding duplications/multiduplications of haplotype.

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