International Scholarly Research Notices / 2013 / Article / Tab 7 / Research Article
Analysis of CYP2D6 Allele Frequencies and Identification of Novel SNPs and Sequence Variations in Sardinians Table 7 CYP2D6 genotype frequencies in 250 healthy Sardinian people. In these results, “Sardinian haplotypes 1 and 2” are considered as part of CYP2D6 *41 allele, instead “Sardinian haplotypes 3 and 4” are considered as part of CYP2D6 *2 allele.
Genotype Observed frequency (%) Predicted frequency (%) Predicted enzymatic activity [5 ]
*
1/ 1 9.6 9.9 EM
*
1/ 2 13.2 12.9 EM
*
1/ 3 1.6 1.7 IM
*
1/ 4 10.0 10.7 IM
*
1/ 5 0.8 0.6 IM
*
1/ 6 0.4 0.2 IM
*
1/ 9 0.4 0.2 IM
*
1/ 10 3.2 3.5 IM
*
1/ 15 0.4 0.5 IM
*
1/ 20 0.4 0.2 IM
*
1/ 28 0.4 0.5 EM/IM ª
*
1/ 35 0.8 0.6 EM
*
1/ 41 10.4 10.9 IM
*
1/ 1 × N 0.8 0.6 UM
*
1/ 2 × N 0.8 0.6 UM
*
2/ 2 4.0 4.3 EM
*
2/ 3 0.8 1.1 IM
*
2/ 4 6.8 6.9 IM
*
2/ 5 0.4 0.5 IM
*
2/ 10 2.4 2.2 IM
*
2/ 28 0.4 0.5 EM/IM ª
*
2/ 35 0.4 0.5 EM
*
2/ 41 7.6 7.1 IM
*
2/ 1 × N 0.4 0.5 UM
*
2/ 2 × N 0.4 0.5 UM
*
3/ 4 0.8 0.9 PM
*
3/ 10 0.4 0.3 IM
*
3/ 41 0.8 0.3 IM
*
4/ 4 2.8 2.9 PM
*
4/ 5 0.4 0.3 PM
*
4/ 10 2.0 1.8 IM
*
4/ 15 0.4 0.3 PM
*
4/ 28 0.4 0.3 IM/PM ª
*
4/ 35 0.4 0.3 IM
*
4/ 41 6.0 5.8 IM
*
4/ 1 × N 0.4 0.3 EM
*
4/ 2 × N 0.4 0.3 EM
*
5/ 41 0.4 0.3 IM
*
10/ 10 0.4 0.3 IM
*
10/ 41 2.0 1.9 IM
*
15/ 41 0.4 0.2 IM
*
28/ 41 0.4 0.3 IM/PM ª
*
35/ 41 0.4 0.3 IM
*
41/ 41 3.2 3.0 IM
*
41/ 1 × N 0.4 0.3 EM
*
41/ 2 × N 0.4 0.3 EM Other — 1.6
test
value
a CYP2D6 *
28 enzymatic activity is not still described [5 ].
