Table of Contents
ISRN Vascular Medicine
Volume 2013 (2013), Article ID 219479, 7 pages
http://dx.doi.org/10.1155/2013/219479
Research Article

Inflammatory Burden but Not Diabetes Mellitus Influences in Prognosis of Endovascular Revascularization in Peripheral Arterial Disease

Angiology and Vascular Surgery Department, Hospital Universitario de Getafe, 28905 Madrid, Spain

Received 30 November 2012; Accepted 9 January 2013

Academic Editors: F. Braet and J.-J. Li

Copyright © 2013 Silvia Bleda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. To determine the effect of inflammatory preoperative burden on the incidence of reintervention and mortality after endovascular therapy (EVT) and to investigate if diabetes mellitus (DM) is involved in these results. Material and Methods. A prospective cohort study with 12-month follow-up period in patients with peripheral artery disease was carried out. hsCRP and fibrinogen assessments were determined. Results. 85 diabetic and 58 nondiabetic patients were included. An increase between basal hsCRP (11.8 mg/L (10.2; 21.5) versus 4.3 mg/L (1.8; 13.9), ) and fibrinogen levels (450 mg/dL (425; 479.1) versus 369 mg/dL (268; 419), ) and the incidence of death during followup was found. A significant increase between higher hsCRP and fibrinogen basal levels and the incidence of reintervention during the follow-up period was also noted ( and , resp.,). There was no difference between DM and non-DM patients in the 1-year need of reintervention (33.3% versus 45%, , resp.,). Basal hsCRP and fibrinogen levels did not significantly differ between DM and non-DM patients who needed reintervention. Conclusions. The prognosis of the EVT is likely marked by the previous inflammatory load, regardless of DM.