Table of Contents
ISRN Hepatology
Volume 2013, Article ID 237870, 7 pages
Review Article

Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis

Division of Gastroenterology, School of Medicine, Tohoku University, Sendai 9808574, Japan

Received 30 October 2012; Accepted 22 November 2012

Academic Editors: A. M. Concejero, C. Domenicotti, and B. Radosevic-Stasic

Copyright © 2013 Masashi Ninomiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In 1980, Ludwig et al. first reported patients of steatohepatitis who lacked a history of excessive alcohol consumption but showed liver histology resembling alcoholic hepatitis and progression to cirrhosis of the liver accompanied by inflammation and fibrosis. The development of nonalcoholic steatohepatitis (NASH) is associated with obesity, diabetes mellitus, insulin resistance, and hyperlipidemia. However, the pathogenesis of NASH remains incomplete. A “multiple-hit” hypothesis for the pathogenesis of NASH based on an animal model has been proposed and remains a foundation for research in this field. We review the important dietary and genetic animal models and discuss the pathogenesis of NASH.