Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis

Table 1

Dietary models of nonalcoholic fatty liver disease.

Model	Obesity	Insulin resistance	Steatohepatitis	Hepatic fibrosis	Elevated AST and ALT
MCD diet	Weight loss	Hepatic insulin resistance	Yes	Yes	Yes
Choline-deficient, L-amino; acid defined (CDAA) diet	Weight loss	No	Yes	Yes	Yes
Atherogenic diet	—*	Hepatic insulin resistance	Yes	Yes	—
High-fat diet	Weight gain	Yes	Yes	Slight	—
Fructose diet	—	Yes	No	No	Yes
Adiponectin null	Weight gain	Yes	Yes	Yes	Yes
Sfrp5 knockout	Weight gain	Yes	Yes	—	—
Bid null	Weight gain	Yes	Yes	—	—
Fas adipocyte-specific knockout	Weight gain	Yes	No	—	—
IL-6 and TNF null	—	—	No	—	—
LIKK	No change	Yes	No	No	No
NEMO^L-KO	Weight gain	Yes	Yes	—	—
JNK1^−/−	Weight gain	Yes	No (only steatosis)	No	—

*Indicates no data.