Table of Contents
ISRN Infectious Diseases
Volume 2013, Article ID 246737, 26 pages
http://dx.doi.org/10.5402/2013/246737
Research Article

Role of Fat-Soluble Vitamins A and D in the Pathogenesis of Influenza: A New Perspective

Department of Health Policy and Management, School of Health Sciences, College of Public Service, Jackson State University, 350 West Woodrow Wilson Avenue, Room 229, Jackson, MS 39213, USA

Received 4 April 2012; Accepted 3 May 2012

Academic Editors: M. C. W. Chan, N. Kawai, and Y. Lai

Copyright © 2013 Anthony R. Mawson. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. G. Webster, W. J. Bean, O. T. Gorman, T. M. Chambers, and Y. Kawaoka, “Evolution and ecology of influenza A viruses,” Microbiological Reviews, vol. 56, no. 1, pp. 152–179, 1992. View at Google Scholar · View at Scopus
  2. A. D. Langmuir and S. C. Schoenbaum, “The epidemiology of influenza,” Hospital Practice, vol. 11, no. 10, pp. 49–56, 1976. View at Google Scholar · View at Scopus
  3. L. Simonsen, “The global impact of influenza on morbidity and mortality,” Vaccine, vol. 17, supplement 1, pp. S3–S10, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. W. W. Thompson, D. K. Shay, E. Weintraub et al., “Mortality associated with influenza and respiratory syncytial virus in the United States,” Journal of the American Medical Association, vol. 289, no. 2, pp. 179–186, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. H. L. Wang and C. Y. Jiang, “Avian influenza H5N1: an update on molecular pathogenesis,” Science in China, vol. 52, no. 5, pp. 459–463, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. P. LaRussa, “Pandemic novel 2009 H1N1 influenza: what have we learned?” Seminars in Respiratory and Critical Care Medicine, vol. 32, no. 4, pp. 393–399, 2011. View at Google Scholar
  7. E. Spackman, “A brief introduction to the avian influenza virus,” Methods in Molecular Biology, vol. 436, pp. 1–6, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. B. Lewis, “Avian flu to human influenza,” Annual Review of Medicine, vol. 57, pp. 139–154, 2006. View at Google Scholar
  9. G. M. Air and W. G. Laver, “The neuraminidase of influenza virus,” Proteins, vol. 6, no. 4, pp. 341–356, 1989. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Schoch-Spana, “Implications of pandemic influenza for bioterrorism response,” Clinical Infectious Diseases, vol. 31, no. 6, pp. 1409–1413, 2000. View at Google Scholar · View at Scopus
  11. A. W. Mounts, H. Kwong, H. S. Izurieta et al., “Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997,” Journal of Infectious Diseases, vol. 180, no. 2, pp. 505–508, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Neumann, T. Noda, and Y. Kawaoka, “Emergence and pandemic potential of swine-origin H1N1 influenza virus,” Nature, vol. 459, no. 7249, pp. 931–939, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Morens, J. K. Taubenberger, and A. S. Fauci, “The 2009 H1N1 pandemic influenza virus: what next?” MBio, vol. 1, no. 4, article e00211-10, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Eccles, “Understanding the symptoms of the common cold and influenza,” Lancet Infectious Diseases, vol. 5, no. 11, pp. 718–725, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. D. S. C. Hui, “Review of clinical symptoms and spectrum in humans with influenza A/H5N1 infection,” Respirology, vol. 13, supplement 1, pp. S10–S13, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. T. M. Tumpey and J. A. Belser, “Resurrected pandemic influenza viruses,” Annual Review of Microbiology, vol. 63, pp. 79–98, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. D. M. Morens, J. K. Taubenberger, and A. S. Fauci, “Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness,” Journal of Infectious Diseases, vol. 198, no. 7, pp. 962–970, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. N. Abdel-Ghafar, T. Chotpitayasunondh, Z. Gao et al., “Update on avian influenza A (H5N1) virus infection in humans,” New England Journal of Medicine, vol. 358, no. 3, pp. 261–273, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Gu, Z. Xie, Z. Gao et al., “H5N1 infection of the respiratory tract and beyond: a molecular pathology study,” The Lancet, vol. 370, no. 9593, pp. 1137–1145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. de Jong, “H5N1 transmission and disease: observations from the frontlines,” The Pediatric Infectious Disease Journal, vol. 27, no. 10, pp. S54–S56, 2008. View at Google Scholar · View at Scopus
  21. N. L. la Gruta, K. Kedzierska, J. Stambas, and P. C. Doherty, “A question of self-preservation: immunopathology in influenza virus infection,” Immunology and Cell Biology, vol. 85, no. 2, pp. 85–92, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Henry, A. Brotcke, D. S. Weiss, L. J. Thompson, and D. M. Monack, “Type I interferon signaling is required for activation of the inflammasome during Francisella infection,” Journal of Experimental Medicine, vol. 204, no. 5, pp. 987–994, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. T. T. Wang and P. Palese, “Unraveling the mystery of swine influenza virus,” Cell, vol. 137, no. 6, pp. 983–985, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. T. L. Brammer, E. L. Murray, K. Fukuda, H. E. Hall, A. Klimov, N. J. Cox et al., “Surveillance for influenza—United States, 1997-98, 1998-99, and 1999-00 seasons,” Morbidity and Mortality Weekly Report, vol. 51, no. 7, pp. 1–10, 2002. View at Google Scholar · View at Scopus
  25. D. M. Morens, “Influenza-related mortality: considerations for practice and public health,” Journal of the American Medical Association, vol. 289, no. 2, pp. 227–229, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Jefferson, C. Di Pietrantonj, A. Rivetti, G. A. Bawazeer, L. A. Al-Ansary, and E. Ferroni, “Vaccines for preventing influenza in healthy adults,” Cochrane Database of Systematic Reviews, vol. 7, article CD001269, 2010, Update of: Cochrane Database of Systematic Reviews 2007; (2): CD001269. View at Google Scholar
  27. M. T. Osterholm, N. S. Kelley, A. Sommer, and E. A. Belongia, “Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis,” The Lancet Infectious Diseases, vol. 12, no. 1, pp. 36–44, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Dumyati and A. R. Falsey, “Antivirals for influenza: what is their role in the older patient?” Drugs and Aging, vol. 19, no. 10, pp. 777–786, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Moscona, “Neuraminidase inhibitors for influenza,” New England Journal of Medicine, vol. 353, no. 13, pp. 1363–1373, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. M. D. de Jong, T. T. Thanh, T. H. Khanh et al., “Oseltamivir resistance during treatment of influenza A (H5N1) infection,” New England Journal of Medicine, vol. 353, no. 25, pp. 2667–2672, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. R. D. Smith, “Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management,” Social Science and Medicine, vol. 63, no. 12, pp. 3113–3123, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. J. S. M. Peiris, C. M. Chu, V. C. C. Cheng et al., “Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study,” The Lancet, vol. 361, no. 9371, pp. 1767–1772, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. J. J. Cannell, R. Vieth, J. C. Umhau et al., “Epidemic influenza and vitamin D,” Epidemiology and Infection, vol. 134, no. 6, pp. 1129–1140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. J. J. Cannell, R. Vieth, W. Willett et al., “Cod liver oil, vitamin A toxicity, frequent respiratory infections, and the vitamin D deficiency epidemic,” Annals of Otology, Rhinology and Laryngology, vol. 117, no. 11, pp. 864–870, 2008. View at Google Scholar · View at Scopus
  35. J. J. Cannell, M. Zasloff, C. F. Garland, R. Scragg, and E. Giovanucci, “On the epidemiology of influenza,” Virology Journal, vol. 5, article 29, 2008. View at Publisher · View at Google Scholar
  36. J. J. Cannell, “Epidemic influenza and vitamin D,” http://www.medicalnewstoday.com/medicalnews.php?newsd=51913.
  37. T. T. Wang, F. P. Nestel, V. Bourdeau et al., “Cutting edge: 1,25-Dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression,” Journal of Immunology, vol. 173, no. 5, pp. 2909–2912, 2004. View at Google Scholar · View at Scopus
  38. R. E. Hope-Simpson and D. B. Golubev, “A new concept of the epidemic process of influenza A virus,” Epidemiology and Infection, vol. 99, no. 1, pp. 5–54, 1987. View at Google Scholar · View at Scopus
  39. R. E. Hope-Simpson, The Transmission of Epidemic Influenza, Plenum Press, New York, NY, USA, 1992.
  40. T. Jefferson, “Influenza vaccination: policy versus evidence,” British Medical Journal, vol. 333, no. 7574, pp. 912–915, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. P. G. Szilagyi, G. Fairbrother, M. R. Griffin et al., “Influenza vaccine effectiveness among children 6 to 59 months of age during 2 influenza seasons: a case-cohort study,” Archives of Pediatrics & Adolescent Medicine, vol. 162, pp. 943–951, 2008. View at Google Scholar
  42. N. J. Cox and K. Subbarao, “Influenza,” The Lancet, vol. 354, no. 9186, pp. 1277–1282, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. E. Hyppönen and C. Power, “Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors,” American Journal of Clinical Nutrition, vol. 85, no. 3, pp. 860–868, 2007. View at Google Scholar · View at Scopus
  44. D. MacDonald and R. Swaminathan, “Seasonal variation in 25-OH vitamin D in plasma of Hong Kong Chinese,” Clinical Chemistry, vol. 34, no. 11, p. 2375, 1988. View at Google Scholar · View at Scopus
  45. A. W. C. Kung and K. K. Lee, “Knowledge of vitamin D and perceptions and attitudes toward sunlight among Chinese middle-aged and elderly women: a population survey in Hong Kong,” BMC Public Health, vol. 6, article 226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. H. I. Hall, D. S. May, R. A. Lew, H. K. Koh, and M. Nadel, “Sun protection behaviors of the U.S. white population,” Preventive Medicine, vol. 26, no. 4, pp. 401–407, 1997. View at Publisher · View at Google Scholar · View at Scopus
  47. I. Laaksi, J. P. Ruohola, P. Tuohimaa et al., “An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men,” American Journal of Clinical Nutrition, vol. 86, no. 3, pp. 714–717, 2007. View at Google Scholar · View at Scopus
  48. M. F. Holick, “Vitamin D deficiency,” The New England Journal of Medicine, vol. 357, pp. 266–281, 2007. View at Google Scholar
  49. A. F. Gombart, N. Borregaard, and H. P. Koeffler, “Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3,” The FASEB Journal, vol. 19, no. 9, pp. 1067–1077, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. J. F. Aloia and M. Li-Ng, “Re: epidemic influenza and vitamin D,” Epidemiology and Infection, vol. 135, no. 7, pp. 1095–1098, 2007. View at Google Scholar · View at Scopus
  51. J. S. Adams and M. Hewison, “Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity,” Nature Clinical Practice Endocrinology and Metabolism, vol. 4, no. 2, pp. 80–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Zasloff, “Antimicrobial peptides of multicellular organisms,” Nature, vol. 415, no. 6870, pp. 389–395, 2002. View at Publisher · View at Google Scholar · View at Scopus
  53. E. Leikina, H. Delanoe-Ayari, K. Melikov et al., “Carbohydrate-binding molecules inhibit viral fusion at the airway surface by transactivation of the epithelial growth factor receptor,” Nature Immunology, vol. 6, pp. 995–1001, 2005. View at Google Scholar
  54. D. M. Laube, S. Yim, L. K. Ryan, K. O. Kisich, and G. Diamond, “Antimicrobial peptides in the airway,” Current Topics in Microbiology and Immunology, vol. 306, pp. 153–182, 2006. View at Google Scholar
  55. J. Schauber, R. A. Dorschner, A. B. Coda et al., “Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism,” Journal of Clinical Investigation, vol. 117, no. 3, pp. 803–811, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at Scopus
  57. L. Sun, C. M. Finnegan, T. Kish-Catalone et al., “Human β-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection,” Journal of Virology, vol. 79, no. 22, pp. 14318–14329, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. M. E. Klotman and T. L. Chang, “Defensins in innate antiviral immunity,” Nature Reviews Immunology, vol. 6, no. 6, pp. 447–456, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. D. Bruce, J. H. Ooi, S. Yu, and M. T. Cantorna, “Vitamin D and host resistance to infection? Putting the cart in front of the horse,” Experimental Biology and Medicine, vol. 235, no. 8, pp. 921–927, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. M. Urashima, T. Segawa, M. Okazaki, M. Kurihara, Y. Wada, and H. Ida, “Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren,” American Journal of Clinical Nutrition, vol. 91, no. 5, pp. 1255–1260, 2010. View at Publisher · View at Google Scholar · View at Scopus
  61. T. L. Clemens, J. S. Adams, S. L. Henderson, and M. F. Holick, “Increased skin pigment reduces the capacity of skin to synthesise vitamin D3,” The Lancet, vol. 1, no. 8263, pp. 74–76, 1982. View at Google Scholar · View at Scopus
  62. B. Srivastava, P. Błazejewska, M. Hessmann et al., “Host genetic background strongly influences the response to influenza a virus infections,” PLoS One, vol. 4, no. 3, Article ID e4857, 2009. View at Publisher · View at Google Scholar · View at Scopus
  63. C. Hoffmann and G. Eichele, “Retinoids in development,” in The Retinoids: Biology, Chemistry, and Medicine, M. B. Sporn, A. B. Roberts, and D. S. Goodman, Eds., pp. 387–441, Raven Press, New York, NY, USA, 1994. View at Google Scholar
  64. M. Theodosiou, V. Laudet, and M. Schubert, “From carrot to clinic: an overview of the retinoic acid signaling pathway,” Cellular and Molecular Life Sciences, vol. 67, no. 9, pp. 1423–1445, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. M. A. Lane and S. J. Bailey, “Role of retinoid signalling in the adult brain,” Progress in Neurobiology, vol. 75, no. 4, pp. 275–293, 2005. View at Publisher · View at Google Scholar · View at Scopus
  66. G. Litwack, Ed., Vitamin A: Vitamins and Hormones, vol. 75, Elsevier Academic Press, San Diego, Calif, USA, 2007.
  67. S. Manicassamy and B. Pulandran, “Retinoic acid-dependent regulation of immune responses by dentritic cells and macrophage,” Semin Immunol, vol. 21, pp. 22–27, 2009. View at Google Scholar
  68. D. J. Mangelsdorf, C. Thummel, M. Beato et al., “The nuclear receptor super-family: the second decade,” Cell, vol. 83, no. 6, pp. 835–839, 1995. View at Google Scholar · View at Scopus
  69. P. Huang, V. Chandra, and F. Rastinejad, “Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics,” Annual Review of Physiology, vol. 72, pp. 247–272, 2010. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Pfahl and F. Chytil, “Regulation of metabolism by retinoic acid and its nuclear receptors,” Annual Review of Nutrition, vol. 16, pp. 257–283, 1996. View at Google Scholar · View at Scopus
  71. C. B. Nilsson and H. Håkansson, “The retinoid signaling system—a target in dioxin toxicity,” Critical Reviews in Toxicology, vol. 32, no. 3, pp. 211–232, 2002. View at Google Scholar · View at Scopus
  72. R. Blomhoff and H. K. Blomhoff, “Overview of retinoid metabolism and function,” Journal of Neurobiology, vol. 66, no. 7, pp. 606–630, 2006. View at Publisher · View at Google Scholar · View at Scopus
  73. G. J. Fisher, S. Datta, Z. Wang et al., “c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid,” Journal of Clinical Investigation, vol. 106, no. 5, pp. 663–670, 2000. View at Google Scholar · View at Scopus
  74. T. T. Schug, D. C. Berry, N. S. Shaw, S. N. Travis, and N. Noy, “Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors,” Cell, vol. 129, no. 4, pp. 723–733, 2007. View at Publisher · View at Google Scholar · View at Scopus
  75. M. A. Leo and C. S. Lieber, “New pathway for retinol metabolism in liver microsomes,” Journal of Biological Chemistry, vol. 260, no. 9, pp. 5228–5231, 1985. View at Google Scholar · View at Scopus
  76. K. L. Penniston and S. A. Tanumihardjo, “The acute and chronic toxic effects of vitamin A,” American Journal of Clinical Nutrition, vol. 83, no. 2, pp. 191–201, 2006. View at Google Scholar · View at Scopus
  77. D. M. Kochar, “Teratogenic activity of retinoic acid,” Acta Pathol Microbiol Scand, vol. 70, pp. 398–404, 1967. View at Google Scholar
  78. R. K. Miller, A. G. Hendricks, J. L. Mills, H. Hummler, and U. W. Weigand, “Periconceptional vitamin A use: how much is teratogenic?” Reproductive Toxicology, vol. 12, pp. 75–88, 1998. View at Google Scholar
  79. J. A. Olson, “Vitamin A—functions, dietary requirements and safety in humans,” in Present Knowledge in Nutrition, E. E. Ziegler and L. J. Filer Jr., Eds., pp. 109–119, International Life Sciences Institute Press, Washington, DC, USA, 7th edition, 2001. View at Google Scholar
  80. L. H. Allen and M. Haskell, “Estimating the potential for vitamin A toxicity in women and young children,” Journal of Nutrition, vol. 132, no. 9, pp. 2907S–2919S, 2002. View at Google Scholar · View at Scopus
  81. D. Coghlan and N. E. Cranswick, “Complementary medicine and vitamin A toxicity in children,” Medical Journal of Australia, vol. 175, no. 4, pp. 223–224, 2001. View at Google Scholar · View at Scopus
  82. Institute of Medicine, Food and Nutrition-Based Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Iron, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academy Press, Washington, DC, USA, 2001.
  83. A. Vahlquist, “Vitamin A in human skin: I. Detection and identification of retinoids in normal epidermis,” Journal of Investigative Dermatology, vol. 79, no. 2, pp. 89–93, 1982. View at Google Scholar · View at Scopus
  84. A. Vahlquist, J. B. Lee, G. Michaelsson, and O. Rollman, “Vitamin A in human skin: II. Concentrations of carotene, retinol and dehydroretinol in various components of normal skin,” Journal of Investigative Dermatology, vol. 79, no. 2, pp. 94–97, 1982. View at Google Scholar · View at Scopus
  85. G. Tang, A. R. Webb, R. M. Russell, and M. F. Holick, “Epidermis and serum protect but not retinyl esters from sunlight-induced photodegradation,” Photodermatology Photoimmunology and Photomedicine, vol. 10, no. 1, pp. 1–7, 1994. View at Google Scholar · View at Scopus
  86. M. A. Pathak and T. B. Fitzpatrick, “Preventive treatment of sunburn, dermatoheliosis, and skin cancer with sun-protective agents,” in Dermatology in General Medicine, T. Fitzpatrick, A. Z. Eisen, K. Wolff, I. M. Freedberg, K. F. Austen et al., Eds., vol. 1-2, chapter 137, pp. 1689–1716, McGraw-Hill, New York, NY, USA, 4th edition, 1993. View at Google Scholar
  87. H. F. DeLuca, H. M. Zile, and P. F. Neville, in Lipid Chromatographic Analysis, A. P. Marinette-Guido, Ed., vol. 2, pp. 345–349, Marcel Dekker, New York, NY, USA, 1979.
  88. M. A. Everett, E. Yeargers, R. M. Sayre, and R. L. Olson, “Penetration of epidermis by ultraviolet rays,” Photochemistry and Photobiology, vol. 5, no. 7, pp. 533–542, 1966. View at Google Scholar · View at Scopus
  89. J. A. Parrish et al., UV-A. Biological Effects of Ultraviolet Radiation with Emphasis on Human Response to Longwave Ultraviolet, Plenum, New York, NY, USA, 1978.
  90. G. H. Findlay and L. W. van der Merwe, “Epidermal vitamin A and sunburn in man,” British Journal of Dermatology, vol. 77, no. 12, pp. 622–626, 1965. View at Google Scholar · View at Scopus
  91. E. Andersson, I. Rosdahl, H. Törmä, and A. Vahlquist, “Ultraviolet irradiation depletes cellular retinol and alters the metabolism of retinoic acid in cultured human keratinocytes and melanocytes,” Melanoma Research, vol. 9, no. 4, pp. 339–346, 1999. View at Google Scholar · View at Scopus
  92. I. Clark and C. A. Bassett, “The amelioration of hypervitaminosis D in rats with vitamin A,” The Journal of Experimental Medicine, vol. 115, pp. 147–156, 1962. View at Google Scholar · View at Scopus
  93. R. Sánchez-Martínez, A. I. Castillo, A. Steinmeyer, and A. Aranda, “The retinoid X receptor ligand restores defective signalling by the vitamin D receptor,” EMBO Reports, vol. 7, no. 10, pp. 1030–1034, 2006. View at Publisher · View at Google Scholar · View at Scopus
  94. C. Masterjohn, “Vitamin D toxicity redefined: vitamin K and the molecular mechanism,” Medical Hypotheses, vol. 68, no. 5, pp. 1026–1034, 2007. View at Publisher · View at Google Scholar · View at Scopus
  95. A. F. Morgan, L. Kimmel, and N. C. Hawkins, “A comparison of the hypervitaminosis induced by irradiated ergosterol and fish liver oil concentrates,” The Journal of Biological Chemistry, vol. 120, no. 1, pp. 85–102, 1937. View at Google Scholar
  96. A. Aburto, H. M. Edwards Jr., and W. M. Britton, “The influence of vitamin a on the utilization and amelioration of toxicity of cholecalciferol, 25-hydroxycholecalciferol, and 1,25 dihydroxycholecalciferol in young broiler chickens,” Poultry Science, vol. 77, no. 4, pp. 585–593, 1998. View at Google Scholar · View at Scopus
  97. A. Aburto and W. M. Britton, “Effects of different levels of vitamins A and E on the utilization of cholecalciferol by broiler chickens,” Poultry Science, vol. 77, no. 4, pp. 570–577, 1998. View at Google Scholar · View at Scopus
  98. A. M. Myhre, M. H. Carlsen, S. K. Bøhn, H. L. Wold, P. Laake, and R. Blomhoff, “Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations,” American Journal of Clinical Nutrition, vol. 78, no. 6, pp. 1152–1159, 2003. View at Google Scholar · View at Scopus
  99. D. Feskanich, V. Singh, W. C. Willett, and G. A. Colditz, “Vitamin A intake and hip fractures among postmenopausal women,” Journal of the American Medical Association, vol. 287, no. 1, pp. 47–54, 2002. View at Google Scholar · View at Scopus
  100. D. K. Dhanwal, C. Cooper, E. M. Dennison et al., “Geographic variation in osteoporotic hip fracture incidence: the growing importance of Asian influences in coming decades,” Journal of Osteoporosis, vol. 2010, Article ID 757102, 5 pages, 2010. View at Publisher · View at Google Scholar
  101. S. Johansson and H. Melhus, “Vitamin A antagonizes calcium response to vitamin D in man,” Journal of Bone and Mineral Research, vol. 16, no. 10, pp. 1899–1905, 2001. View at Google Scholar · View at Scopus
  102. C. M. Rohde and H. F. DeLuca, “All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats,” Journal of Nutrition, vol. 135, no. 7, pp. 1647–1652, 2005. View at Google Scholar · View at Scopus
  103. K. Oh, W. C. Willett, K. Wu, C. S. Fuchs, and E. L. Giovannucci, “Calcium and vitamin D intakes in relation to risk of distal colorectal adenoma in women,” American Journal of Epidemiology, vol. 165, no. 10, pp. 1178–1186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  104. J. S. Adams and B. W. Hollis, “Vitamin D synthesis, metabolism, and clinical measurement,” in Diseases of Bone and Mineral Metabolism, F. L. Coe and M. J. Favus, Eds., p. 159, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2002. View at Google Scholar
  105. R. P. Heaney, “The Vitamin D requirement in health and disease,” Journal of Steroid Biochemistry and Molecular Biology, vol. 97, no. 1-2, pp. 13–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  106. H. M. Page, E. S. Erwin, and G. E. Nelms, “Effect of heat and solar radiation on vitamin A utilization by the bovine animal,” American Journal of Physiology, vol. 196, pp. 917–918, 1959. View at Google Scholar
  107. H. K. Biesalski and D. Nohr, “New aspects in vitamin A metabolism: the role of retinyl esters as systemic and local sources for retinol in mucous epithelia,” Journal of Nutrition, vol. 134, supplement 12, pp. 3453S–3457S, 2004. View at Google Scholar · View at Scopus
  108. M. Maden and M. Hind, “Retinoic acid in alveolar development, maintenance and regeneration,” Philosophical Transactions of the Royal Society, vol. 359, no. 1445, pp. 799–808, 2004. View at Publisher · View at Google Scholar · View at Scopus
  109. Y. P. Di, R. Harper, Y. Zhao, N. Pahlavan, W. Finkbeiner, and R. Wu, “Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts,” Journal of Biological Chemistry, vol. 278, no. 2, pp. 1165–1173, 2003. View at Publisher · View at Google Scholar · View at Scopus
  110. Morbidity and Mortality Weekly Reports, “Prevention and control of influenza,” Recommendations of the Advisory Committee on Immunization Practices (ACIP) 53, pp. 1–44, Morbidity and Mortality Weekly Report, 2004. View at Google Scholar
  111. N. K. Polakos, J. C. Cornejo, D. A. Murray et al., “Kupffer call-dependent hepatitis occurs during influenza infection,” The American Journal of Pathology, vol. 168, pp. 1169–1178, 2006. View at Google Scholar
  112. D. H. Adams and S. G. Hubscher, “Systemic viral infections and collateral damage in the liver,” American Journal of Pathology, vol. 168, no. 4, pp. 1057–1059, 2006. View at Publisher · View at Google Scholar · View at Scopus
  113. J. R. Whitworth, C. L. Mack, J. A. O'Connor, M. R. Narkewicz, S. Mengshol, and R. J. Sokol, “Acute hepatitis and liver failure associated with influenza a infection in children,” Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 4, pp. 536–538, 2006. View at Publisher · View at Google Scholar · View at Scopus
  114. S. R. Frankel, A. Eardley, G. Lauwers, M. Weiss, and R. P. Warrell, “The “retinoic acid syndrome” in acute promyelocytic leukemia,” Annals of Internal Medicine, vol. 117, no. 4, pp. 292–296, 1992. View at Google Scholar · View at Scopus
  115. S. Sacchi, H. M. Kantarjian, E. J. Freireich et al., “Unexpected high incidence of severe toxicities associated with alpha interferon, low-dose cytosine arabinoside and all-trans retinoic acid in patients with chronic myelogenous leukemia,” Leukemia and Lymphoma, vol. 35, no. 5-6, pp. 483–489, 1999. View at Google Scholar · View at Scopus
  116. R. Costello, R. Bouabdallah, and J.-A. Gastaut, “Pseudo-“acid retinoic syndrome“ mimicked by severe influenza A infection,” American Journal of Hematology, vol. 52, p. 120, 1996. View at Publisher · View at Google Scholar · View at Scopus
  117. L. E. Davis, M. Kornfeld, R. S. Daniels, and J. J. Skehel, “Experimental influenza causes a non-permissive viral infection of brain, liver and muscle,” Journal of NeuroVirology, vol. 6, no. 6, pp. 529–536, 2000. View at Google Scholar · View at Scopus
  118. D. M. Aboulafia, D. Norris, D. Henry et al., “9-cis-retinoic acid capsules in the treatment of AIDS-related Kaposi sarcoma: results of a phase 2 multicenter clinical trial,” Archives of Dermatology, vol. 139, no. 2, pp. 178–186, 2003. View at Publisher · View at Google Scholar · View at Scopus
  119. C. Sandrock and T. Kelly, “Clinical review: update of avian influenza A infections in humans,” Critical Care, vol. 11, no. 2, article 209, 2007. View at Publisher · View at Google Scholar · View at Scopus
  120. M. J. Fredette, G. de Serres, and M. Malenfant, “Ophthalmological and biological features of the oculorespiratory syndrome after influenza vaccination,” Clinical Infectious Diseases, vol. 37, no. 8, pp. 1136–1138, 2003. View at Publisher · View at Google Scholar · View at Scopus
  121. F. T. Fraunfelder, F. W. Fraunfelder, and R. Edwards, “Ocular side effects possibly associated with isotretinoin usage,” American Journal of Ophthalmology, vol. 132, no. 3, pp. 299–305, 2001. View at Publisher · View at Google Scholar · View at Scopus
  122. R. D. Semba, “Vitamin A as “anti-infective” therapy, 1920–1940,” Journal of Nutrition, vol. 129, no. 4, pp. 783–791, 1999. View at Google Scholar · View at Scopus
  123. S. K. Stansfield, M. Pierre-Louis, G. Lerebours, and A. Augustin, “Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections,” The Lancet, vol. 342, no. 8871, pp. 578–582, 1993. View at Publisher · View at Google Scholar · View at Scopus
  124. I. Grotto, M. Mimouni, M. Gdalevich, and D. Mimouni, “Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis,” Journal of Pediatrics, vol. 142, no. 3, pp. 297–304, 2003. View at Publisher · View at Google Scholar · View at Scopus
  125. C. B. Stephensen, L. M. Franchi, H. Hernandez, M. Campos, R. H. Gilman, and J. O. Alvarez, “Adverse effects of high-dose vitamin A supplements in children hospitalized with pneumonia,” Pediatrics, vol. 101, no. 5, p. E3, 1998. View at Google Scholar · View at Scopus
  126. D. Cui, Z. Moldoveanu, and C. B. Stephensen, “High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice,” Journal of Nutrition, vol. 130, no. 5, pp. 1132–1139, 2000. View at Google Scholar · View at Scopus
  127. H. Chen, Q. Zhuo, W. Yuan, J. Wang, and T. Wu, “Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age,” Cochrane Database of Systematic Reviews, no. 1, article CD006090, 2008. View at Publisher · View at Google Scholar · View at Scopus
  128. J. Ni, J. Wei, and T. Wu, “Vitamin A for non-measles pneumonia in children,” Cochrane Database of Systematic Reviews, no. 3, p. CD003700, 2005. View at Google Scholar · View at Scopus
  129. P. Ghazal, J. LeBlanc, and A. Angulo, “Vitamin A regulation of viral growth,” Reviews in Medical Virology, vol. 7, pp. 21–34, 1997. View at Google Scholar
  130. D. Wolff, C. Sinzger, P. Drescher, G. Jahn, and B. Plachter, “Reduced levels of IE2 gene expression and shutdown of early and late viral genes during latent infection of the glioblastoma cell line U138-MG with selectable recombinants of human cytomegalovirus,” Virology, vol. 204, no. 1, pp. 101–113, 1994. View at Publisher · View at Google Scholar · View at Scopus
  131. P. Ghazal, C. DeMattei, E. Giulietti, S. A. Kliewer, K. Umesono, and R. M. Evans, “Retinoic acid receptors initiate induction of the cytomegalovirus enhancer in embryonal cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 16, pp. 7630–7634, 1992. View at Google Scholar · View at Scopus
  132. A. Angulo, R. A. R. Chandraratna, J. F. LeBlanc, and P. Ghazal, “Ligand induction of retinoic acid receptors alters an acute infection by murine cytomegalovirus,” Journal of Virology, vol. 72, no. 6, pp. 4589–4600, 1998. View at Google Scholar · View at Scopus
  133. J. A. Turpin, M. Vargo, and M. S. Meltzer, “Enhanced HIV-1 replication in retinoid-treated monocytes: retinoid effects mediated through mechanisms related to cell differentiation and to a direct transcriptional action on viral gene expression,” Journal of Immunology, vol. 148, no. 8, pp. 2539–2546, 1992. View at Google Scholar · View at Scopus
  134. M. O. Lee, P. D. Hobbs, X. K. Zhang, M. I. Dawson, and M. Pfahl, “A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promotor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, pp. 5632–5636, 1994. View at Google Scholar
  135. R. J. Jones, S. Dickerson, P. M. Bhenda et al., “Epstein-Barr virus lytic infection induces retinoic acid-responsive genes through of a retinol-metabolizing enzyme, DHRS9,” Journal of Biological Chemistry, vol. 282, no. 11, pp. 8317–8324, 2007. View at Google Scholar
  136. T. Ichinohe, A. Iwasaki, and H. Hasegawa, “Innate sensors of influenza virus: clues to developing better intranasal vaccines,” Expert Review of Vaccines, vol. 7, no. 9, pp. 1435–1445, 2008. View at Publisher · View at Google Scholar · View at Scopus
  137. A. Iwasaki and R. Medzhitov, “Toll-like receptor control of the adaptive immune responses,” Nature Immunology, vol. 5, no. 10, pp. 987–995, 2004. View at Publisher · View at Google Scholar · View at Scopus
  138. J. M. Lund, L. Alexopoulou, A. Sato et al., “Recognition of single-stranded RNA viruses by Toll-like receptor 7,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 15, pp. 5598–5603, 2004. View at Publisher · View at Google Scholar · View at Scopus
  139. B. Pulendran, “Tolls and beyond—many roads to vaccine immunity,” New England Journal of Medicine, vol. 356, no. 17, pp. 1776–1778, 2007. View at Publisher · View at Google Scholar · View at Scopus
  140. J. Sirén, T. Imaizumi, D. Sarkar et al., “Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines,” Microbes and Infection, vol. 8, no. 8, pp. 2013–2020, 2006. View at Publisher · View at Google Scholar · View at Scopus
  141. H. Kato, S. Sato, M. Yoneyama et al., “Cell type-specific involvement of RIG-I in antiviral response,” Immunity, vol. 23, no. 1, pp. 19–28, 2005. View at Publisher · View at Google Scholar · View at Scopus
  142. S. S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. R. E. Sousa, “Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA,” Science, vol. 303, no. 5663, pp. 1529–1531, 2004. View at Publisher · View at Google Scholar · View at Scopus
  143. T. Hennet, H. J. Ziltener, K. Frei, and E. Peterhans, “A kinetic study of immune mediators in the lungs of mice infected with influenza A virus,” Journal of Immunology, vol. 149, no. 3, pp. 932–939, 1992. View at Google Scholar · View at Scopus
  144. J. Pirhonen, T. Sareneva, M. Kurimoto, I. Julkunen, and S. Matikainen, “Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway,” Journal of Immunology, vol. 162, no. 12, pp. 7322–7329, 1999. View at Google Scholar · View at Scopus
  145. N. Schmitz, M. Kurrer, M. F. Bachmann, and M. Kopf, “Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection,” Journal of Virology, vol. 79, no. 10, pp. 6441–6448, 2005. View at Publisher · View at Google Scholar · View at Scopus
  146. J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, “Foxp3 programs the development and function of CD4+CD25+ regulatory T cells,” Nature Immunology, vol. 4, no. 4, pp. 330–336, 2003. View at Publisher · View at Google Scholar · View at Scopus
  147. J. Dai, B. Liu, and Z. Li, “Regulatory T cells and Toll-like receptors: what is the missing link?” International Immunopharmacology, vol. 9, no. 5, pp. 528–533, 2009. View at Publisher · View at Google Scholar · View at Scopus
  148. C. M. Sun, J. A. Hall, R. B. Blank et al., “Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1775–1785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  149. J. L. Coombes, K. R. R. Siddiqui, C. V. Arancibia-Cárcamo et al., “A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β and retinoic acid-dependent mechanism,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1757–1764, 2007. View at Publisher · View at Google Scholar · View at Scopus
  150. S. Uematsu, K. Fujimoto, M. H. Jang et al., “Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5,” Nature Immunology, vol. 9, no. 7, pp. 769–776, 2008. View at Publisher · View at Google Scholar · View at Scopus
  151. C. H. Kim, “Regulation of FoxP3+ regulatory T cells and Th17 cells by retinoids,” Clinical and Developmental Immunology, vol. 2008, Article ID 416910, 12 pages, 2008. View at Google Scholar
  152. D. Mucida, Y. Park, G. Kim et al., “Reciprocal Th17 and regulatory T cell differentiation mediated by retinoic acid,” Science, vol. 317, no. 5835, pp. 256–260, 2007. View at Publisher · View at Google Scholar · View at Scopus
  153. M. Iwata, A. Hirakiyama, Y. Eshima, H. Kagechika, C. Kato, and S. Y. Song, “Retinoic acid imprints gut-homing specificity on T cells,” Immunity, vol. 21, no. 4, pp. 527–538, 2004. View at Publisher · View at Google Scholar · View at Scopus
  154. J. F. Bermejo-Martin, I. Martin-Loeches, J. Rello et al., “Host adaptive immunity deficiency in severe pandemic influenza,” Critical Care, vol. 14, no. 5, R167, 2010. View at Google Scholar
  155. J. Louten, K. Boniface, and R. de Waal Malefyt, “Development and function of TH17 cells in health and disease,” Journal of Allergy and Clinical Immunology, vol. 123, no. 5, pp. 1004–1011, 2009. View at Publisher · View at Google Scholar · View at Scopus
  156. G. Krstić, “Th17 mediators and vitamin D status,” Critical Care, vol. 14, no. 2, article 410, 2010. View at Publisher · View at Google Scholar · View at Scopus
  157. J. P. Wang, G. N. Bowers, C. Padden et al., “Toll-like receptor-mediated activation of neutrophils by influenza virus,” Blood, vol. 112, pp. 2028–2034, 2008. View at Google Scholar
  158. M. D. de Jong, C. P. Simmons, T. T. Thanh et al., “Fatal outcome of human influenza A (H5N1) is associated wth high viral-load and hypercytokinemia,” Nature Medicine, vol. 12, no. 10, pp. 1203–1207, 2006. View at Google Scholar
  159. N. D. Lawson and N. Berliner, “Neutrophil maturation and the role of retinoic acid,” Experimental Hematology, vol. 27, pp. 1355–1367, 1999. View at Google Scholar
  160. K. Mehta, “Retinoic acid—a player that rules the game of life and death in neutrophils,” Indian Journal of Experimental Biology, vol. 40, no. 8, pp. 874–881, 2002. View at Google Scholar · View at Scopus
  161. K. A. Daher, M. E. Selsted, and R. I. Lehrer, “Direct inactivation of viruses by human granulocyte defensins,” Journal of Virology, vol. 60, no. 3, pp. 1068–1074, 1986. View at Google Scholar · View at Scopus
  162. R. I. Lehrer, “Multispecific myeloid defensins,” Current Opinion in Hematology, vol. 14, no. 1, pp. 16–21, 2007. View at Google Scholar · View at Scopus
  163. H. Koga, I. Fujita, and S. Miyazaki, “Effects of all-trans-retinoic acid on superoxide generation in intact neutrophils and a cell-free system,” British Journal of Haematology, vol. 97, no. 2, pp. 300–305, 1997. View at Google Scholar · View at Scopus
  164. S. S. Twining, D. P. Schulte, P. M. Wilson, B. L. Fish, and J. E. Moulder, “Vitamin A deficiency alters rat neutrophil function,” Journal of Nutrition, vol. 127, no. 4, pp. 558–565, 1997. View at Google Scholar · View at Scopus
  165. J. Jagdeo, R. Campbell, T. Long, J. Muglia, G. Telang, and L. Robinson-Bostom, “Sweet's syndrome-like neutrophilic lobular panniculitis associated with all-trans-retinoic acid chemotherapy in a patient with acute promyelocytic leukemia,” Journal of the American Academy of Dermatology, vol. 56, no. 4, pp. 690–693, 2007. View at Publisher · View at Google Scholar · View at Scopus
  166. Y. Zhao, M. Lu, L. T. Lau et al., “Neutrophils may be a vehicle for viral replication and dissemination in human H5N1 avian influenza,” Clinical Infectious Diseases, vol. 47, no. 12, pp. 1575–1578, 2008. View at Publisher · View at Google Scholar · View at Scopus
  167. L. Kaiser, R. S. Fritz, S. E. Straus, L. Gubareva, and F. G. Hayden, “Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses,” Journal of Medical Virology, vol. 64, no. 3, pp. 262–268, 2001. View at Publisher · View at Google Scholar · View at Scopus
  168. M. L. Heltzer, S. E. Coffin, K. Maurer et al., “Immune dysregulation in severe influenza,” Journal of Leukocyte Biology, vol. 85, no. 6, pp. 1036–1043, 2009. View at Publisher · View at Google Scholar · View at Scopus
  169. N. Krishnamoorthy, T. B. Oriss, M. Paglia et al., “Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma,” Nature Medicine, vol. 14, no. 5, pp. 565–573, 2008. View at Publisher · View at Google Scholar · View at Scopus
  170. M. Iwata, Y. Eshima, and H. Kagechika, “Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors,” International Immunology, vol. 15, no. 8, pp. 1017–1025, 2003. View at Publisher · View at Google Scholar · View at Scopus
  171. J. R. Mora, M. Iwata, B. Eksteen et al., “Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells,” Science, vol. 314, no. 5802, pp. 1157–1160, 2006. View at Publisher · View at Google Scholar · View at Scopus
  172. H. Asano, M. Aonuma, T. Sanosaka, J. Kohyama, M. Namihira, and K. Nakashima, “Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification,” Stem Cells, vol. 27, no. 11, pp. 2744–2752, 2009. View at Publisher · View at Google Scholar · View at Scopus
  173. F. Herrera, Q. Chen, and D. Schubert, “Synergistic effect of retinoic acid and cytokines on the regulation of glial fibrillary acidic protein expression,” Journal of Biological Chemistry, vol. 285, no. 50, pp. 38915–38922, 2010. View at Publisher · View at Google Scholar · View at Scopus
  174. S. Oh, J. M. Mccaffery, and M. C. Eichelberger, “Dose-dependent changes in influenza virus-infected dendritic cells result in increased allogeneic T-cell proliferation at low, but not high, doses of virus,” Journal of Virology, vol. 74, no. 12, pp. 5460–5469, 2000. View at Publisher · View at Google Scholar · View at Scopus
  175. T. P. Welliver, J. L. Reed, and R. C. Welliver Sr., “Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases,” The Pediatric Infectious Disease Journal, vol. 27, no. 10, pp. S92–S96, 2008. View at Google Scholar · View at Scopus
  176. D. Proud, “Nitric oxide and the common cold,” Current Opinion in Allergy and Clinical Immunology, vol. 5, no. 1, pp. 37–42, 2005. View at Google Scholar · View at Scopus
  177. C. Watanabe, H. Kawashima, K. Takekuma, A. Hoshika, and Y. Watanabe, “Increased nitric oxide production and GFAP expression in the brains of influenza A/NWS virus infected mice,” Neurochemical Research, vol. 33, no. 6, pp. 1017–1023, 2008. View at Publisher · View at Google Scholar · View at Scopus
  178. D. Personett, U. Pass, K. Panickar, and M. McKinney, “Retinoic acid-mediated enhancement of the cholinergic/neuronal nitric oxide synthase phenotype of the medial septal SN56 clone: establishment of a nitric oxide-sensitive proapoptotic state,” Journal of Neurochemistry, vol. 74, no. 6, pp. 2412–2424, 2000. View at Publisher · View at Google Scholar · View at Scopus
  179. S. Moncada, R. M. J. Palmer, and E. A. Higgs, “Nitric oxide: physiology, pathophysiology, and pharmacology,” Pharmacological Reviews, vol. 43, no. 2, pp. 109–142, 1991. View at Google Scholar · View at Scopus
  180. K. Mehta, T. McQueen, S. Tucker, R. Pandita, and B. B. Aggarwal, “Inhibition of all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages,” Journal of Leukocyte Biology, vol. 55, no. 3, pp. 336–342, 1994. View at Google Scholar · View at Scopus
  181. K. Hirokawa, K. M. O'Shaughnessy, P. Ramrakha, and M. R. Wilkins, “Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids,” British Journal of Pharmacology, vol. 113, no. 4, pp. 1448–1454, 1994. View at Google Scholar · View at Scopus
  182. K. Motomura, H. Sakai, H. Isobe, and H. Nawata, “Effects of retinoids on the production of tumour necrosis factor-alpha and nitric oxide by lipopolysaccharide stimulated rat Kupffer cells in vitro: evidence for participation of retinoid X receptor signalling pathway,” Cell Biochemistry and Function, vol. 15, no. 2, pp. 95–101, 1997. View at Publisher · View at Google Scholar · View at Scopus
  183. A. Sirsjö, A. C. Gidlöf, A. Olsson et al., “Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-α,” Biochemical and Biophysical Research Communications, vol. 270, no. 3, pp. 846–851, 2000. View at Publisher · View at Google Scholar · View at Scopus
  184. A. Duchini, M. E. Viernes, L. M. Nyberg, R. M. Hendry, and P. J. Pockros, “Hepatic decompensation in patients with cirrhosis during infection with influenza A,” Archives of Internal Medicine, vol. 160, no. 1, pp. 113–115, 2000. View at Google Scholar · View at Scopus
  185. A. B. Barua, P. K. Duitsman, D. Kostic, M. Barua, and J. A. Olson, “Reduction of serum retinol levels following a single oral dose of all-trans retinoic acid in humans,” International Journal for Vitamin and Nutrition Research, vol. 67, no. 6, pp. 423–426, 1997. View at Google Scholar · View at Scopus
  186. C. S. Lieber and M. A. Leo, “Interaction of alcohol and nutritional factors with hepatic fibrosis,” Progress in Liver Diseases, vol. 8, pp. 253–272, 1986. View at Google Scholar · View at Scopus
  187. Z. Dan, Y. Popov, E. Patsenker et al., “Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential,” The FASEB Journal, vol. 19, no. 7, pp. 845–847, 2005. View at Publisher · View at Google Scholar · View at Scopus
  188. W. Sim, E. Abril, and D. Earnest, “Mechanisms of Kupffer cell activation in hypervitaminosis A,” in Cells of the Hepatic Sinusoid, E. Wisse, D. Knook, and K. Decker, Eds., pp. 91–93, The Kupffer Cell Foundation, Rijswijk, The Netherlands, 1989. View at Google Scholar
  189. S. A. Mobley, W. Sim, and I. G. Sipes, “Repeated exposure to subclinical doses of hepatotoxicant enhances liver injury with hypervitaminosis A: a possible cause for chronic liver disease,” Gastroenterology, vol. 96, p. A689, 1989. View at Google Scholar
  190. R. M. Russell, J. L. Boyer, S. A. Bagheri, and Z. Hruban, “Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites,” New England Journal of Medicine, vol. 291, no. 9, pp. 435–440, 1974. View at Google Scholar · View at Scopus
  191. R. Cheruvattath, M. Orrego, M. Gautam et al., “Vitamin A toxicity: when one a day doesn't keep the doctor away,” Liver Transplantation, vol. 12, no. 12, pp. 1888–1891, 2006. View at Publisher · View at Google Scholar · View at Scopus
  192. V. S. Ramanathan, G. Hensley, S. French et al., “Hypervitaminosis A inducing intra-hepatic cholestasis—a rare case report,” Experimental and Molecular Pathology, vol. 88, no. 2, pp. 324–325, 2010. View at Publisher · View at Google Scholar · View at Scopus
  193. D. Li and S. L. Friedman, “Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy,” Journal of Gastroenterology and Hepatology, vol. 14, no. 7, pp. 618–633, 1999. View at Publisher · View at Google Scholar · View at Scopus
  194. M. Okuno, S. Kojima, K. Akita et al., “Retinoids in liver fibrosis and cancer,” Front Biosci, vol. 7, pp. d204–d218, 2002. View at Google Scholar · View at Scopus
  195. J. Mann and D. A. Mann, “Transcriptional regulation of hepatic stellate cells,” Advanced Drug Delivery Reviews, vol. 61, no. 7-8, pp. 497–512, 2009. View at Publisher · View at Google Scholar · View at Scopus
  196. H. Popper and F. Schaffner, “Cholestasis,” in Gastroenterology, J. E. Berk, Ed., vol. 5, chapter 148, pp. 2697–2731, WB Saunders, Philadelphia, Pa, USA, 4th edition, 1985. View at Google Scholar
  197. C. A. Frolik, “Metabolism of retinoids,” in The Retinoids, M. B. Sporn, A. B. Roberts, and D. S. Goodman, Eds., pp. 177–208, Academic Press, New York, NY, USA, 1984. View at Google Scholar
  198. V. A. Hicks, D. B. Gunning, and J. A. Olson, “Metabolism, plasma transport and biliary excretion of radioactive vitamin A and its metabolites as a function of liver reserves of vitamin A in the rat,” Journal of Nutrition, vol. 114, no. 7, pp. 1327–1333, 1984. View at Google Scholar · View at Scopus
  199. A. K. Mitra, J. O. Alvarez, M. A. Wahed, G. J. Fuchs, and C. B. Stephensen, “Predictors of serum retinol in children with shigellosis,” American Journal of Clinical Nutrition, vol. 68, no. 5, pp. 1088–1094, 1998. View at Google Scholar · View at Scopus
  200. F. J. Schweigert, “Inflammation-induced changes in the nutritional biomarkers serum retinol and carotenoids,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 4, no. 6, pp. 477–481, 2001. View at Publisher · View at Google Scholar · View at Scopus
  201. S. H. Gieng, M. H. Green, J. B. Green, and F. J. Rosales, “Model-based compartmental analysis indicates a reduced mobilization of hepatic vitamin A during inflammation in rats,” Journal of Lipid Research, vol. 48, no. 4, pp. 904–913, 2007. View at Publisher · View at Google Scholar · View at Scopus
  202. E. Mezey, “Liver disease and protein needs,” Annual Review of Nutrition, vol. 2, pp. 21–50, 1982. View at Google Scholar · View at Scopus
  203. T. R. Martin and C. W. Frevert, “Innate immunity in the lungs,” Proceedings of the American Thoracic Society, vol. 2, no. 5, pp. 403–411, 2005. View at Google Scholar
  204. T. M. Tumpey, X. Lu, T. Morken, S. R. Zaki, and J. M. Katz, “Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans,” Journal of Virology, vol. 74, no. 13, pp. 6105–6116, 2000. View at Publisher · View at Google Scholar · View at Scopus
  205. I. A. Clark, L. M. Alleva, and B. Vissel, “The roles of TNF in brain dysfunction and disease,” Pharmacology & Therapeutics, vol. 128, no. 3, pp. 519–548, 2010. View at Google Scholar
  206. T. Gustot, F. Durand, D. Lebrec, J. L. Vincent, and R. Moreau, “Severe sepsis in cirrhosis,” Hepatology, vol. 50, no. 6, pp. 2022–2033, 2009. View at Publisher · View at Google Scholar · View at Scopus
  207. A. Ukleja, J. S. Scolapio, J. P. McConnell et al., “Nutritional assessment of serum and hepatic vitamin A levels in patients with cirrhosis,” Journal of Parenteral and Enteral Nutrition, vol. 26, no. 3, pp. 184–188, 2002. View at Google Scholar · View at Scopus
  208. H. Maeda and T. Akaike, “Nitric oxide and oxygen radicals in infection, inflammation and cancer,” Biochemistry, vol. 63, no. 7, pp. 854–865, 1998. View at Google Scholar · View at Scopus
  209. D. Ungheri, C. Pinasi, G. Sanson et al., “Protective effect of N-acetylcysteine in a model of influenza infection in mice,” International Journal of Immunopathology and Pharmacology, vol. 13, no. 3, pp. 123–128, 2000. View at Google Scholar · View at Scopus
  210. R. Harrison, “Structure and function of xanthine oxidoreductase: where are we now?” Free Radical Biology and Medicine, vol. 33, no. 6, pp. 774–797, 2002. View at Publisher · View at Google Scholar · View at Scopus
  211. G. Taibi, A. Paganini, M. C. Gueli, F. Ampola, and C. M. A. Nicotra, “Xanthine oxidase catalyzes the synthesis of retinoic acid,” Journal of Enzyme Inhibition, vol. 16, no. 3, pp. 275–285, 2001. View at Google Scholar · View at Scopus
  212. A. Kumar, R. Zarychanski, R. Pinto et al., “Hospitalized patients with 2009 H1N1 influenza in the United States, April–June 2009,” The New England Journal of Medicine, vol. 361, pp. 1935–1944, 2009. View at Google Scholar
  213. J. F. Bermejo-Martin, R. Ortiz de Lejarazu, T. Pumarola et al., “Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza,” Critical Care, vol. 13, no. 6, p. R201, 2009. View at Google Scholar · View at Scopus
  214. Centers for Disease Control and Prevention (CDC), “Intensive-care patients with severe novel influenza A (H1N1) virus infection—Michigan, June 2009,” Morbidity and Mortality Weekly Report, vol. 58, no. 27, pp. 749–752, 2009. View at Google Scholar
  215. C. Venkata, P. Sampathkumar, and B. Afessa, “Hospitalized patients with 2009 H1N1 influenza infection: the mayo clinic experience,” The Mayo Clinic Proceedings, vol. 85, no. 9, pp. 798–805, 2010. View at Publisher · View at Google Scholar · View at Scopus
  216. Q. Yang, T. E. Graham, N. Mody et al., “Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes,” Nature, vol. 436, no. 7049, pp. 356–362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  217. T. E. Graham, Q. Yang, M. Blüher et al., “Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects,” New England Journal of Medicine, vol. 354, no. 24, pp. 2552–2563, 2006. View at Publisher · View at Google Scholar · View at Scopus
  218. C. C. Chen, J. Y. Wu, C. T. Chang et al., “Levels of retinol-binding protein 4 and uric acid in patients with type 2 diabetes mellitus,” Metabolism, vol. 58, no. 12, pp. 1812–1816, 2009. View at Publisher · View at Google Scholar · View at Scopus
  219. C. Erikstrup, O. H. Mortensen, A. R. Nielsen et al., “RBP-to-retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes,” Diabetes, Obesity and Metabolism, vol. 11, no. 3, pp. 204–212, 2009. View at Publisher · View at Google Scholar · View at Scopus
  220. A. R. Mawson, W. Bennett, S. Tanumihardjo et al., “Altered retinoid profiles in an animal model of preeclampsia, gestational diabetes and fetal growth restriction,” Reproductive Sciences, vol. 17, supplement 3, abstract 592, p. 235A, 2010. View at Google Scholar
  221. C. F. Basler, “Influenza viruses: basic biology and potential drug targets,” Infectious Disorders, vol. 7, no. 4, pp. 282–293, 2007. View at Publisher · View at Google Scholar · View at Scopus
  222. D. S. Fedson, “Confronting an influenza pandemic with inexpensive generic agents: can it be done?” The Lancet Infectious Diseases, vol. 8, no. 9, pp. 571–576, 2008. View at Publisher · View at Google Scholar · View at Scopus
  223. J. Bassaganya-Riera, R. Song, P. C. Roberts, and R. Hontecillas, “PPAR-γ activation as an anti-inflammatory therapy for respiratory virus infections,” Viral Immunology, vol. 23, no. 4, pp. 343–352, 2010. View at Publisher · View at Google Scholar · View at Scopus
  224. J. M. Katz, J. Plowden, M. Renshaw-Hoelscher et al., “Immunity to influenza: the challenges of protecting an aging population,” Immunology Research, vol. 29, no. 1-3, pp. 113–124, 2004. View at Google Scholar
  225. P. J. Garry, W. C. Hunt, J. L. Bandrofchak, D. VanderJagt, and J. S. Goodwin, “Vitamin A intake and plasma retinol levels in healthy elderly men and women,” American Journal of Clinical Nutrition, vol. 46, no. 6, pp. 989–994, 1987. View at Google Scholar · View at Scopus
  226. G. W. Comstock, M. S. Menkes, S. E. Schober, J. P. Vuilleumier, and K. J. Helsing, “Serum levels of retinol, beta-carotene, and alpha-tocopherol in older adults,” American Journal of Epidemiology, vol. 127, no. 1, pp. 114–123, 1988. View at Google Scholar · View at Scopus
  227. D. Sklan, S. Trifon, O. Kedar, N. Vaisman, and Y. Berner, “Retinoid metabolism in human leucocytes,” British Journal of Nutrition, vol. 73, no. 6, pp. 889–895, 1995. View at Publisher · View at Google Scholar · View at Scopus
  228. D. Hollander and V. Dadufalza, “Influence of aging on vitamin A transport into the lymphatic circulation,” Experimental Gerontology, vol. 25, no. 1, pp. 61–65, 1990. View at Publisher · View at Google Scholar · View at Scopus
  229. S. D. Krasinski, J. S. Kohn, E. J. Schaefer, and R. M. Russell, “Post prandial plasma retinyl ester response is greater in older subjects compared with younger subjects,” Journal of Clinical Investigation, vol. 85, pp. 883–892, 1990. View at Google Scholar
  230. J. B. Johnson, D. R. Laub, and S. John, “The effect on health of alternate day calorie restriction: eating less and more than needed on alternate days prolongs life,” Medical Hypotheses, vol. 67, no. 2, pp. 209–211, 2006. View at Publisher · View at Google Scholar · View at Scopus
  231. T. Akaike, M. Ando, T. Oda et al., “Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice,” Journal of Clinical Investigation, vol. 85, no. 3, pp. 739–745, 1990. View at Google Scholar · View at Scopus
  232. C. Apfel, F. Bauer, M. Crettaz et al., “A retinoic acid receptor α antagonist selectively counteracts retinoic acid effects,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 15, pp. 7129–7133, 1992. View at Publisher · View at Google Scholar · View at Scopus