Synthesis, Crystal Structure, Antioxidant, Antimicrobial, and Mutagenic Activities and DNA Interaction Studies of Ni(II) Schiff Base 4-Methoxy-3-benzyloxybenzaldehyde Thiosemicarbazide Complexes

Table 8

Selected cleavage data of SC pUC19 by ligand and its complexes 1, 2, and 3.

Lane no.	Conditions	[Complex] µM	^aSC%	^bNC%
1	DNA control	—	97	3
2	DNA + Ligand + H2O2	60	92	8
3	DNA + Ligand + MPA	60	93	7
4	DNA + 1 + MPA	60	90	10
5	DNA + 2 + MPA	60	87	13
6	DNA + 3 + MPA	60	89	11
7	DNA + 1 + H2O2	60	78	22
8	DNA + 2 + H2O2	60	65	35
9	DNA + 3 + H2O2	60	75	25

aSC: supercoiled DNA.
^bNC: nicked circular DNA.