The Role of Neurotransmitters in Protection against Amyloid-β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons

Figure 4

Effect of opioid receptor antagonism on KiSS-1 gene overexpression neuroprotection against amyloid-β toxicity. PKiSS cells were pretreated with (a) opioid antagonist naloxone (NAL: 1 μM) or (b) opioid antagonist naltrexone (NALTR: 1 μM) for 2 h prior to exposure to Aβ 1–40 (10 μM) and determination of viability by MTT reduction. Results are mean ± s.e.m. *𝑃<0.05 versus control (media alone); ^†𝑃<0.05 versus Aβ alone; one-way ANOVA.

(a)

(b)