The Role of Neurotransmitters in Protection against Amyloid-β Toxicity by KiSS-1 Overexpression in SH-SY5Y Neurons
Figure 9
Effect of serotonergic receptor antagonism on KiSS-1 gene overexpression neuroprotection against amyloid-β toxicity. PKiSS cells were pretreated with (a) serotonergic antagonist cyproheptadine hydrochloride (CYPR: 10 nM) or (b) serotonergic antagonist methysergide maleate (MET: 1 μM) for 2 h prior to exposure to Aβ 1–40 (10 μM) and determination of viability by MTT reduction. Results are mean ± s.e.m. * versus control (media alone); † versus Aβ alone; one-way ANOVA.
