Figure 4: Effect of rimcazole (3 mg/kg; s.c) on the antitussive effects of dex (dextromethorphan 10 mg/kg; i.p.), codeine (10 mg/kg; i.p.), and Tc (ethyl acetate fraction of Terminalia chebula 250 and 500 mg/kg; i.p.). Rimcazole was administered 45 min before cough challenge. Codeine and dextromethorphan were administered 30 min before cough induction, and testing material was administered 60 min before cough induction in mice. Each column represents mean with SEM for at least 8 mice. Significant differences from saline control were indicated as * and ** by Student’s -test.