Increased Occurrence of Valproic Acid-Induced Hyperammonemia in Carriers of T1405N Polymorphism in Carbamoyl Phosphate Synthetase 1 Gene

<table>Distribution of individual blood ammonia concentrations at the time of enrollment according to patients carrier status for minor allele in T1405N polymorphism  (noncarriers = 0, carriers = 1). Vertical axis—blood ammonia concentrations in <i>μ</i>mol/L. The horizontal line denotes the threshold level of diagnosis of hyperammonemia.</table>

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Figure 1

Figure 1: Increased Occurrence of Valproic Acid-Induced Hyperammonemia in Carriers of T1405N Polymorphism in Carbamoyl Phosphate Synthetase 1 Gene 