Table of Contents
ISRN Neurology
Volume 2013 (2013), Article ID 261497, 4 pages
http://dx.doi.org/10.1155/2013/261497
Research Article

Increased Occurrence of Valproic Acid-Induced Hyperammonemia in Carriers of T1405N Polymorphism in Carbamoyl Phosphate Synthetase 1 Gene

1Laboratory of Perioperative Genomics and Anesthetic Preoperative Evaluation Clinic, Department of Anesthesiology, Pennsylvania State University College of Medicine, MS Hershey Medical Center, H187, 500 University Drive, Hershey, PA 17033, USA
2Department of Experimental and Clinical Pharmacology, Warsaw Medical University, Krakowskie Przedmiescie 26/28, 00-927 Warsaw, Poland
3Department of Neurology, Pennsylvania State University MS Hershey Medical Center, H187, 500 University Drive, Hershey, PA 17033, USA
42nd Department Neurology, National Institute of Psychiatry and Neurology, Ulica Sobieskiego 9, 02-957 Warsaw, Poland

Received 7 June 2013; Accepted 6 July 2013

Academic Editors: N. Bresolin and T. Kato

Copyright © 2013 Piotr K. Janicki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Mittal, S. Muralee, and R. R. Tampi, “Valproic acid-induced hyperammonemia in the elderly: a review of the literature,” Case Reports in Medicine, vol. 2009, Article ID 802121, 5 pages, 2009. View at Publisher · View at Google Scholar
  2. A. Chopra, B. P. Kolla, M. P. Mansukhani, P. Netzel, and M. A. Frye, “Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management,” General Hospital Psychiatry, vol. 34, no. 3, pp. 290–298, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Lewis, A. Deshpande, G. E. Tesar et al., “Valproate-induced hyperammonemic encephalopathy: a brief review,” Current Medical Research and Opinion, vol. 28, pp. 1039–1042, 2012. View at Google Scholar
  4. M. Yagi, T. Nakamura, Y. Okizuka et al., “Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia,” Pediatrics International, vol. 52, no. 5, pp. 744–748, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Bezinover, M. Postula, K. Donahue, B. Bentzen, J. McInerney, and P. K. Janicki, “Perioperative exacerbation of valproic acid-associated hyperammonemia: a clinical and genetic analysis,” Anesthesia and Analgesia, vol. 113, no. 4, pp. 858–861, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Yamamoto, Y. Takahashi, E. Suzuki et al., “Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients,” Epilepsy Research, vol. 101, pp. 202–209, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. H. B. C. Verbiest, J. S. Straver, J. P. Colombo, J. C. M. van der Vijver, and T. C. A. M. van Woerkom, “Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma,” Acta Neurologica Scandinavica, vol. 86, no. 3, pp. 275–279, 1992. View at Google Scholar · View at Scopus
  8. N. Segura-Bruna, A. Rodriguez-Campello, V. Puente, and J. Roquer, “Valproate-induced hyperammonemic encephalopathy,” Acta Neurologica Scandinavica, vol. 114, no. 1, pp. 1–7, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. D. L. Pearson, S. Dawling, W. F. Walsh et al., “Neonatal pulmonary hypertension: Urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function,” The New England Journal of Medicine, vol. 344, no. 24, pp. 1832–1838, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. M. L. Summar, J. V. Gainer, M. Pretorius et al., “Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function,” Hypertension, vol. 43, no. 2 I, pp. 186–191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. M. J. Moonen, A. D. C. Paulussen, N. Y. P. Souren, A. G. H. Kessels, M. E. Rubio-Gozalbo, and E. Villamor, “Carbamoyl phosphate synthetase polymorphisms as a risk factor for necrotizing enterocolitis,” Pediatric Research, vol. 62, no. 2, pp. 188–190, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. M. J. Moonen, I. Reyes, G. Cavallaro, G. González-Luis, J. A. Bakker, and E. Villamor, “The T1405N carbamoyl phosphate synthetase polymorphism does not affect plasma arginine concentrations in preterm infants,” PloS ONE, vol. 5, no. 5, Article ID e10792, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Bezinover, L. Douthitt, P. M. McQuillan et al., “Fatal hyperammonemia after renal transplant due to late-onset urea cycle deficiency: a case report,” Transplantation Proceedings, vol. 42, no. 5, pp. 1982–1985, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Garg and R. A. Sunder, “Valproate-induced hyperammonemia and seizures: perioperative concerns,” Paediatric Anaesthesia, vol. 21, no. 10, pp. 1084–1085, 2011. View at Publisher · View at Google Scholar · View at Scopus