Table of Contents
ISRN Microbiology
Volume 2013 (2013), Article ID 272086, 5 pages
http://dx.doi.org/10.1155/2013/272086
Research Article

The Effect of Gold and Iron-Oxide Nanoparticles on Biofilm-Forming Pathogens

1Department of Biomedical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamilnadu 603110, India
2Department of Chemical Engineering, SSN College of Engineering, Old Mahabalipuram Road, Kalavakkam, Tamilnadu 603110, India

Received 31 July 2013; Accepted 29 August 2013

Academic Editors: P. Di Martino and N. S. Jakubovics

Copyright © 2013 Madhu Bala Sathyanarayanan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel. Here, we studied the effect of gold and iron oxide nanoparticles on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We report that biofilm growth was reduced at higher concentrations of gold and iron-oxide nanoparticles compared to absence of nanoparticles. Thus nanoparticles with appropriate concentration could show significant reduction in biofilm formation.