Table of Contents
ISRN Ophthalmology
Volume 2013, Article ID 273085, 9 pages
Clinical Study

Association of Reticular Pseudodrusen and Early Onset Drusen

1Department of Ophthalmology, Croix-Rousse University Hospital, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France
2Professor Sahel Department, Rothschild Ophthalmologic Foundation, 25 rue Manin, 75019 Paris, France
3Kleber Retinal Center, 50 Cours Franklin Roosevelt, 69006 Lyon, France
4Department of Ophthalmology, Gui de Chauliac University Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France

Received 2 April 2013; Accepted 28 April 2013

Academic Editors: J. O. Croxatto, M. Nakazawa, L. Pierro, Y. F. Shih, and M. Sugimoto

Copyright © 2013 Flore De Bats et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes) with EOD were examined. EOD were classified into three entities called Large Colloid Drusen (LCD), Malattia Leventinese (ML), and Cuticular Drusen (CD). Best-corrected visual acuity, fundus examination, color fundus photographs, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and SD-OCT were performed in all study patients. Results. Four patients had LCD, 2 had ML, and 2 had CD. Reticular pseudodrusen were observed with SD-OCT in all study patients; all these patients had hyperreflective lesions above and below the RPE. Conclusion. Early Onset Drusen appear to be associated with reticular pseudodrusen. SD-OCT is helpful in distinguishing the location of the deposits that are above and below the RPE in EOD. Further studies are needed to understand the role of reticular pseudodrusen in the pathophysiology of EOD.