Table of Contents
ISRN Endocrinology
Volume 2013 (2013), Article ID 307925, 6 pages
http://dx.doi.org/10.1155/2013/307925
Research Article

No Association between Glycemia and Wound Healing in an Experimental db/db Mouse Model

1Institute of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway
2Department of Organ Transplantation, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway

Received 7 August 2013; Accepted 11 September 2013

Academic Editors: O. Giampietro, S. M. Hileman, and E. Spinedi

Copyright © 2013 Margrete Berdal and Trond Jenssen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Impaired wound healing is a frequent problem in diabetes. Hyperglycemia may be an operative mechanism, but a link between glycemic control and wound healing has never been established. Wounds in db/db mice have been extensively studied. This study was undertaken to see if plasma glucose was a predictor of wound healing. An excisional wound was made (149 db/db mice). Wound closure was studied versus metabolic variables. The animals were weeks (mean ± standard error of the mean), obese ( g), and hyperglycemic (fasting plasma glucose  mmol/L). Wound closure at day 13 was . In linear mixed model analyses neither fasting plasma glucose nor its change from start to end of experiment was a significant predictor of wound closure (, , 95% CI: −0.01 to 0.31 and , , 95% CI: −0.11 to 0.23, resp.). However, increase in body weight significantly and independently predicted wound closure (for weight change, , , 95% CI: 0.06 to 0.38). This study strongly suggests that wound healing in db/db mice is independent of prevailing glycemia but dependent on anabolic changes such as weight gain over time.