No Association between Glycemia and Wound Healing in an Experimental db/db Mouse Model

Table 2

Adjusted estimates for age and metabolic variables from 149 diabetic db/db mice in linear mixed model (LMM) analyses with wound closure at day 13 as the dependent variable.

Predictor variables	Standardized estimate	P value	95% CI for the estimate
ageday0 (weeks)	0.06	0.71	−0.25 to 0.36
wtday7 (g)	−0.06	0.49	−0.25 to 0.12
wtday7--13 (%)	0.22	0.008	0.06 to 0.38
fPGday0 (mmol/L)	0.15	0.07	−0.01 to 0.31
ΔfPGday0--end (%)	0.06	0.47	−0.11 to 0.23
p-Lactateday0 (mmol/L)	−0.02	0.69	−0.14 to 0.09

The model was adjusted for the variation between batches of animals by means of LMM. Tests of potential interactions (Δwt_day7--13×fPG_day0, Δwt_day7--13  ×  ΔfPG_day0--end) adjusted for ageday0, wtday7, Δwtday7--13, fPGday0, ΔfPGday0-end, and plasma lactate_day0 were nonsignificant (𝛽=0.04, 𝑃=0.85, and 95% CI −0.35 to 0.42; 𝛽=−0.08, 𝑃=0.34, and 95% CI −0.25 to 0.09, resp.). Day 0: the day of wounding; wt_day7: body weight 7 days after wounding; Δwtday7--13: body weight change between days 7 and 13; fPG: fasting plasma glucose; ΔfPGday0--end: the change in fPG from day 0 to the end of experiment; p-lactate: plasma lactate.