Table of Contents
ISRN Endocrinology
Volume 2013 (2013), Article ID 321063, 4 pages
http://dx.doi.org/10.1155/2013/321063
Clinical Study

Routine Screening for Cushing's Syndrome Is Not Required in Patients Presenting with Obesity

1Department of Endocrinology and Metabolism Disease, Recep Tayyip Erdogan University Medical School, 53020 Rize, Turkey
2Department of Family Medicine, Recep Tayyip Erdogan University Medical School, Rize, Turkey
3Department of Internal Medicine, Recep Tayyip Erdogan University Medical School, Rize, Turkey

Received 7 May 2013; Accepted 2 June 2013

Academic Editors: C.-H. Anderwald, C. Bizzarri, C. N. Mowa, and G. F. Wagner

Copyright © 2013 Serap Baydur Sahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Cushing’s syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. Our aim was to evaluate the frequency of CS in obese patients. Materials and Methods. This study included 354 consecutive patients (87.9% female, age years) who presented with simple obesity. All the patients were evaluated for the clinical signs of CS. Lipid parameters, fasting glucose (FPG) and insulin, 75 gr oral glucose tolerance test, basal cortisol and ACTH were measured. 1 mg overnight DST was performed. Results. The mean weight of the patients was  kg and BMI  kg/m2. 34.5% of the patients were hypertensive. 36.2% of the patients had central obesity, 72% dorsocervical fat accumulation, 28.8% abdominal striae and 23.2% acne. 49.4% of the women had hirsutism. 46.5% had prediabetes and 12.0% had type 2 diabetes, 72.6% had dyslipidemia. The mean cortisol and ACTH levels were as follows: μg/dL and  pg/mL. Seven patients failed to suppress plasma cortisol to less than 1.8 μg/dL. Biochemical confirmation tests were performed in these patients and 2 of them were diagnosed glucocorticoid-secreting adrenal adenoma. Conclusions. Routine screening for CS in obese patients is not required.