Glomerular Disease in Patients with Infectious Processes Developing Antineutrophil Cytoplasmic Antibodies

Table 4

Abnormal laboratory tests in 50 patients with infections, ANCA positivity, and glomerular disease.

Laboratory test	Number of patients tested	Percent of tests with abnormality
Hematology
Anemia^1	23 (E: 16, O: 7)	96 (E: 100, O: 86)
Leucocytosis^2	31 (E: 14, O: 17)	45 (E: 29, O: 59)
Leucopenia^3	31 (E: 14, O: 17)	13 (E: 21, O: 6)
Shift to the left^4	11 (E: 8, O: 3)	64 (E: 63, O: 67)
Thrombocytopenia^5	17 (E: 13, O: 4)	24 (E: 23, O: 25)
Tests of inflammation
Elevated Erythrocyte sedimentation rate^6	22 (E: 8, O: 14)	100
Elevated C-reactive protein	28 (E: 19, O: 9)	93 (E: 100, O: 78)
Low C3 complement component	32 (E: 19, O: 13)	56 (E: 63, O: 46)
Low C4 complement component	35 (E: 22, O: 13)	46 (E: 45, O: 46)
Low CH50 complement component	20 (E: 9, O: 11)	60 (E: 67, O: 55)
Serum autoantibodies
Positive antinuclear antibody	27 (E: 16, O: 11)	33 (E: 44, O: 18)
Positive cryoglobulins	19 (E: 11, O: 8)	32 (E: 36, O: 25)
Elevated rheumatoid factor	19 (E: 11, O: 8)	68 (E: 73, O: 63)
Positive c-ANCA^7	33 (E: 24, O: 9)	64 (E: 63, O: 67)
Positive antiproteinase-3 (anti-PR-3)^8	35 (E: 24, O: 11)	60 (E: 71, O: 36)
Positive p-ANCA^7	35 (E: 25, O: 10)	31 (E: 32, O: 30)
Positive antimyeloperoxidase (anti-MPO)^8	36 (E: 24, O: 12)	39 (E: 38, O: 42)

E: endocarditis, O: Other infections. ¹Blood hemoglobin (Hgb) < 13 gm/dL. No difference between E and O. For all 27 subjects, mean Hgb was 8.4 ± 2.5 gm/dL. ²White blood cell count (WBC) > 10 k/mm³. ³WBC < 4 k/mm³. Mean WBC: E: 9.7 ± 6.8 k/mm³; O: 12.1 ± 8.5 k/mm³. ⁴Neutrophil predominance and/or immature white blood cells in WBC. ⁵Platelet count < 100 k/mm³. No difference between E and O. For all 17 subjects, mean platelet count was 160 ± 85 k/mm³. ⁶Mean erythrocyte sedimentation rate, not different between E and O, was in the 22 patients 77 ± 29 mm/hr. ⁷Measured by immunofluorescence. ⁸Measured by ELISA.