International Scholarly Research Notices / 2013 / Article / Tab 4

Review Article

Glomerular Disease in Patients with Infectious Processes Developing Antineutrophil Cytoplasmic Antibodies

Table 4

Abnormal laboratory tests in 50 patients with infections, ANCA positivity, and glomerular disease.

Laboratory testNumber of patients testedPercent of tests with abnormality

Hematology
 Anemia123 (E: 16, O: 7)96 (E: 100, O: 86)
 Leucocytosis231 (E: 14, O: 17)45 (E: 29, O: 59)
 Leucopenia331 (E: 14, O: 17)13 (E: 21, O: 6)
 Shift to the left411 (E: 8, O: 3)64 (E: 63, O: 67)
 Thrombocytopenia517 (E: 13, O: 4)24 (E: 23, O: 25)
Tests of inflammation
 Elevated Erythrocyte sedimentation rate622 (E: 8, O: 14)
100
 Elevated C-reactive protein28 (E: 19, O: 9)93 (E: 100, O: 78)
 Low C3 complement component32 (E: 19, O: 13)56 (E: 63, O: 46)
 Low C4 complement component35 (E: 22, O: 13)46 (E: 45, O: 46)
 Low CH50 complement component20 (E: 9, O: 11)60 (E: 67, O: 55)
Serum autoantibodies
 Positive antinuclear antibody27 (E: 16, O: 11)33 (E: 44, O: 18)
 Positive cryoglobulins19 (E: 11, O: 8)32 (E: 36, O: 25)
 Elevated rheumatoid factor19 (E: 11, O: 8)68 (E: 73, O: 63)
 Positive c-ANCA733 (E: 24, O: 9)64 (E: 63, O: 67)
 Positive antiproteinase-3 (anti-PR-3)835 (E: 24, O: 11)60 (E: 71, O: 36)
 Positive p-ANCA735 (E: 25, O: 10)31 (E: 32, O: 30)
 Positive antimyeloperoxidase (anti-MPO)836 (E: 24, O: 12)39 (E: 38, O: 42)

E: endocarditis, O: Other infections. 1Blood hemoglobin (Hgb) < 13 gm/dL. No difference between E and O. For all 27 subjects, mean Hgb was 8.4 ± 2.5 gm/dL. 2White blood cell count (WBC) > 10 k/mm3. 3WBC < 4 k/mm3. Mean WBC: E: 9.7 ± 6.8 k/mm3; O: 12.1 ± 8.5 k/mm3. 4Neutrophil predominance and/or immature white blood cells in WBC. 5Platelet count < 100 k/mm3. No difference between E and O. For all 17 subjects, mean platelet count was 160 ± 85 k/mm3. 6Mean erythrocyte sedimentation rate, not different between E and O, was in the 22 patients 77 ± 29 mm/hr. 7Measured by immunofluorescence. 8Measured by ELISA.