Table of Contents
ISRN Dermatology
Volume 2013, Article ID 325246, 3 pages
http://dx.doi.org/10.1155/2013/325246
Clinical Study

Acquired Melanonychia in Chilean Patients with Essential Thrombocythemia Treated with Hydroxyurea: A Report of 7 Clinical Cases and Review of the Literature

1Hematology Department, Hospital de Carabineros, Simon Bolıvar 2200, Nunoa, 7770199 Santiago, Chile
2Faculty of Medicine, University Mayor, Renato Sanchez 4369, Las Condes, 27550224 Santiago, Chile
3Division of Medicine, Hospital de Carabineros, Simon Bolıvar 2200, Nunoa, 7770199 Santiago, Chile
4Faculty of Dentistry, University de Desarrollo, Avenida Las Condes 12.438, Lo Barnechea, 27470325 Santiago, Chile
5Pharmacy Department, Hospital de Carabineros, Simon Bolıvar 2200, Nunoa, 7770199 Santiago, Chile

Received 16 December 2012; Accepted 13 January 2013

Academic Editors: E. Pasmatzi, Y. Tuzun, and J. F. Val Bernal

Copyright © 2013 Nigel P. Murray et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Longitudinal melanonychia has been associated with a range of drugs, especially chemotherapeutic agents. We report 7 cases of melanonychia associated with the use of hydroxycarbamide for essential thrombocythemia. Of a patient population of 27, 7 (26%) developed melanonychia over a period of 2–7 years, and was not dose dependent. The high incidence of melanonychia in Chilean patients may be in part due to their Hispanic descent or to the high levels of UV radiation found in Santiago.