Table of Contents
ISRN Inorganic Chemistry
Volume 2013, Article ID 329508, 7 pages
http://dx.doi.org/10.1155/2013/329508
Research Article

Ligation of Fe(III) and Mn(II) Complexes by Bithiourea and Their Biological Activity

1Department of Chemistry, Federal University of Agriculture Abeokuta, PMB 2240, Abeokuta, Ogun State 11001, Nigeria
2Department of Chemical Sciences, Ajayi Crowther University, PMB 1066, Oyo, Oyo State 200211, Nigeria
3Department of Microbiology, Federal University of Agriculture, PMB 2240, Abeokuta, Ogun State 11001, Nigeria

Received 25 February 2013; Accepted 15 March 2013

Academic Editors: Y. Ding and A. Karadag

Copyright © 2013 J. F. Adediji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Complexes of Fe(III) and Mn(II) with bithiourea were synthesized and characterised by elemental analysis, magnetic measurements, infrared spectroscopy, UV/visible, thin layer chromatography, and conductance measurements. The IR showed that the ligand coordinates through C=S and N–H donor atoms and hence a bidentate. The antimicrobial activity of the complexes formed has been tested and compared with bithiourea at different concentrations in order to obtain some quantitative information about their biological activity towards microorganism. Metal complexes were found to show better activities as compared to the ligand and the standard drug used as control. In vivo toxicological studies showed that the complexes were not toxic at the dosage level administered.