Urea Concentration and Haemodialysis Dose

Table 5

Dialysis with dual targets: minimum std 𝐾/𝑉 and maximum PAC.

Label	Variable	Unit	Group 1		Group 2		Group 3		All
			Mean	SD	Mean	SD	Mean	SD	Mean	SD
𝑁	Number of sessions		205		272		142		619
𝑉	Postdialysis distribution volume	L	34.7	6.3	30.1	6.1	36.1	7.9	33.0	7.1
𝐺	Urea generation rate	μmol/min	143	34	191	40	290	66	198	71
nPCR	Normalised protein catabolic rate	g/kg/day	0.80	0.10	1.14	0.13	1.41	0.21	1.09	0.27
𝐾𝑟	Renal urea clearance	mL/min	0.54	1.06	1.01	1.44	0.66	1.33	0.77	1.31
𝐾𝑑	Dialyser urea clearance	mL/min	189	0	189	0	189	0	189	0
𝑓𝑑	Dialysis frequency	/wk	3.00	0.00	3.00	0.00	5.00	0.00	3.46	0.84
𝑡𝑑	Dialysis time	min	181	44	208	50	177	42	192	48
t𝑑𝑤	Weekly dialysis time	h	9.0	2.2	10.4	2.5	14.7	3.5	11.0	3.4
wUF	Weekly ultrafiltration volume	L	7.99	2.87	7.82	2.86	9.80	2.83	8.33	2.97
TAC	Time-averaged concentration	mmol/L	15.5	2.8	18.2	1.2	19.3	0.9	17.6	2.4
PAC	Average predialysis concentration	mmol/L	20.4	3.4	25.4	0.1	25.4	0.0	23.7	3.1
std EKR	std EKR	/wk	2.70	0.12	3.58	0.65	4.28	0.95	3.45	0.86
std 𝐾/𝑉	std 𝐾/𝑉	/wk	2.05	0.00	2.54	0.34	3.23	0.54	2.54	0.55

Note: the predefined treatment parameters and target values are in bold.