Table of Contents
ISRN Endocrinology
Volume 2013, Article ID 341632, 8 pages
Clinical Study

Human Serum PCSK9 Is Elevated at Parturition in Comparison to Nonpregnant Subjects While Serum PCSK9 from Umbilical Cord Blood is Lower Compared to Maternal Blood

1Clinical Research Laboratory, Division of Endocrinology and Metabolism, Department of Medicine, The Ottawa Hospital, Riverside Campus, University of Ottawa, 1967 Riverside Drive, Ottawa, ON, Canada K1H 7W9
2Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
3Division of Maternal Fetal Medicine, Departments of Obstetrics and Gynaecology and Cellular Molecular Medicine, University of Ottawa, 501 Smyth Road, Box 804, Ottawa, ON, Canada K1H 8L6
4Chronic Disease Program, Ottawa Hospital Research Institute, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, Canada K1H 8L6
5Department of Obstetrics and Gynaecology, Winchester District Memorial Hospital, 566 Louise Street, Winchester, ON, Canada K0C 2K0

Received 9 April 2013; Accepted 15 May 2013

Academic Editors: R. Aikin, W. B. Chan, Y. Combarnous, T. Dinh, and S. Mishra

Copyright © 2013 Patricia Peticca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Scatter plot distributions of serum PCSK9 and lipids for the Maternal subgroups in comparison to the overall Maternal distribution, and for the Maternal subgroups (in both mother and newborn) to the overall Maternal and Newborn distributions of PCSK9 and lipids. Maternal and Newborn samples were subdivided as Normal, PET (pre-eclampsia) and IUGR (intrauterine growth restriction). Pregnancy was defined as Normal if associated with age appropriate fetal weights, in the absence of maternal disease. PET was defined as having maternal blood pressure of >140/90 and proteinuria >300 mg of protein in a 24 hr urine collection, or 2+ protein on urine dipstick. IUGR was defined as an estimated fetal weight below the 5th percentile for gestational age by ultrasound. Dots represent individual subjects. Bars indicate median ± interquartile range. No subgroup comparisons were carried out because subgrouped data were not significantly powered.

  1. Supplementary Figure