Table of Contents
ISRN Biotechnology
Volume 2013, Article ID 341974, 6 pages
Research Article

Encapsulation of Phaseolus lunatus Protein Hydrolysate with Angiotensin-Converting Enzyme Inhibitory Activity

Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Periférico Norte. Km. 33.5, Tablaje Catastral 13615, Col. Chuburná de Hidalgo Inn, CP 97203, Mérida, YUC, Mexico

Received 28 June 2013; Accepted 25 August 2013

Academic Editors: K. R. Davis, I. W. Marison, and J. C. Merchuk

Copyright © 2013 Jorge Carlos Ruiz Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of recent research has been to seek alternative therapeutic treatments; for this reason, the use of protein hydrolysates from diverse sources has been studied. A way to guarantee that these treatments reach the site of action is through protection with covers, such as microcapsules. Therefore, proteins from the legume Phaseolus lunatus were hydrolyzed and encapsulated with a blend of Delonix regia carboxymethylated gum/sodium alginate (50 : 50 w/w). Hydrolysis release conditions in a simulated gastrointestinal system were obtained using CaCl2 concentrations as the main factor, indicating that lower CaCl2 concentrations lead to an increased hydrolysis release. Beads obtained with 1.0 mM of CaCl2 exhibited a better hydrolysate release rate under intestinal simulated conditions and the proteins maintained an IC50 of 2.9 mg/mL. Capsules obtained with the blend of Delonix regia carboxymethylated gum/sodium alginate would be used for the controlled delivery of hydrolysates with potential use as nutraceutical or therapeutic agents.