Immunotherapy with Tolerogenic Dendritic Cells Alone or in Combination with Rapamycin Does Not Reverse Diabetes in NOD Mice
Immunotherapy—alone or in combination with immunosuppressant—does not reverse T1D in NOD mice. Glucose levels in diabetic mice from different groups. White bar corresponds to glycaemia in a group of 8 mice at the onset of the disease. Black bars correspond to different groups at the end of the study (day 30). No significant differences were observed when treated groups were compared to the sham group. Significant differences were found when the NITApo-DCs group was compared with mice treated with rapamycin (Rapa) and with mice treated with tolerogenic DCs and rapamycin (Rapa + NITApo-DCs). Results are means ± SD from 3–6 mice per group. and mean significant differences, and , respectively.