Comparing Drug-Drug Interaction Severity Ratings between Bedside Clinicians and Proprietary Databases

Table 2

Drug-drug interaction rating scale [14, 15].

Rating	Designation	Explanation
X	Contraindicated	Avoid combination	The drugs are contraindicated for concurrent use
D	Major	Consider therapy modification	The interaction may be life threatening and/or require medical
			intervention to minimize or prevent serious adverse events
C	Moderate	Monitor therapy	The interaction may result in exacerbation of the patient's
			condition and/or require an alteration in therapy
B	Minor	No action needed	The interaction would have limited clinical effects. May include an
			increase in the frequency or severity of the side effects, but
			generally it would not require a major alteration in therapy
A	Unknown	No known interaction	Unknown