Table of Contents
ISRN Nanomaterials
Volume 2013, Article ID 348095, 8 pages
http://dx.doi.org/10.1155/2013/348095
Research Article

Screening of Most Effective Variables for Development of Gastroretentive Mucoadhesive Nanoparticles by Taguchi Design

1Department of Pharmaceutics, Oriental College of Pharmacy, Thakral Nagar, Raisen Road, Bhopal, Madhya Pradesh 462021, India
2Department of Pharmacy, Uttarakhand Technical University, Sudhowala, Dehradun, Uttarakhand 248007, India
3Department of Pharmaceutics, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh 462021, India

Received 13 June 2013; Accepted 6 July 2013

Academic Editors: Z. Jiang, Z.-M. Liao, J. Shen, and W. W. Shu

Copyright © 2013 Ankit Anand Kharia and Akhlesh Kumar Singhai. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. J. O'Brien and D. M. Campoli-Richards, “Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy,” Drugs, vol. 37, no. 3, pp. 233–309, 1989. View at Google Scholar · View at Scopus
  2. M. Ruhneck-Forsbeck, E. Sandstrom, and B. Andersson, “Treatment of recurrent genital herpes simplex infections with oral acyclovir,” Journal of Antimicrobial Chemotherapy, vol. 16, no. 5, pp. 621–628, 1985. View at Google Scholar · View at Scopus
  3. Z. Shao and A. K. Mitra, “Bile salt-fatty acid mixed micelles as nasal absorption promoters. III. Effects of nasal transport and enzymatic degradation of acyclovir prodrugs,” Pharmaceutical Research, vol. 11, no. 2, pp. 243–250, 1994. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Gröning, M. Berntgen, and M. Georgarakis, “Acyclovir serum concentrations following peroral administration of magnetic depot tablets and the influence of extracorporal magnets to control gastrointestinal transit,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 46, no. 3, pp. 285–291, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. K. C. Meadows and J. B. Dressman, “Mechanism of acyclovir uptake in rat jejunum,” Pharmaceutical Research, vol. 7, no. 3, pp. 299–303, 1990. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Park and J. R. Robinson, “Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion,” International Journal of Pharmaceutics, vol. 19, no. 2, pp. 107–127, 1984. View at Publisher · View at Google Scholar · View at Scopus
  7. B. N. Singh and K. H. Kim, “Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention,” Journal of Controlled Release, vol. 63, no. 3, pp. 235–259, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Streubel, J. Siepmann, and R. Bodmeier, “Gastroretentive drug delivery systems,” Expert Opinion on Drug Delivery, vol. 3, no. 2, pp. 217–233, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. A. A. Kharia, S. N. Hiremath, A. K. Singhai, L. K. Omray, and S. K. Jain, “Design and optimization of floating drug delivery system of acyclovir,” Indian Journal of Pharmaceutical Sciences, vol. 72, no. 5, pp. 599–606, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Singh, R. Kumar, and N. Ahuja, “Optimizing drug delivery systems using systematic “design of experiments.” Part I: fundamental aspects,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 22, no. 1, pp. 27–105, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Singh, S. K. Chakkal, and N. Ahuja, “Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology,” AAPS PharmSciTech, vol. 7, no. 1, pp. E19–E28, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. B. Singh, S. Pahuja, R. Kapil, and N. Ahuja, “Formulation development of oral controlled release tablets of hydralazine: optimization of drug release and bioadhesive characteristics,” Acta Pharmaceutica, vol. 59, no. 1, pp. 1–13, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Venkata Dasu, T. Panda, and M. Chidambaram, “Determination of significant parameters for improved griseofulvin production in a batch bioreactor by Taguchi's method,” Process Biochemistry, vol. 38, no. 6, pp. 877–880, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. H. L. Luessen, C.-M. Lehr, C.-O. Rentel et al., “Bioadhesive polymers for the peroral delivery of peptide drugs,” Journal of Controlled Release, vol. 29, no. 3, pp. 329–338, 1994. View at Publisher · View at Google Scholar · View at Scopus
  15. G.-B. Park, Z. Shao, and A. K. Mitra, “Acyclovir permeation enhancement across intestinal and nasal mucosae by bile salt-acylcarnitine mixed micelles,” Pharmaceutical Research, vol. 9, no. 10, pp. 1262–1267, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Hejazi and M. Amiji, “Chitosan-based gastrointestinal delivery systems,” Journal of Controlled Release, vol. 89, no. 2, pp. 151–165, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. C. J. Coester, K. Langer, H. Von Briesen, and J. Kreuter, “Gelatin nanoparticles by two step desolvation—a new preparation method, surface modifications and cell uptake,” Journal of Microencapsulation, vol. 17, no. 2, pp. 187–193, 2000. View at Google Scholar · View at Scopus
  18. A. H. Elshafeey, A. O. Kamel, and G. A. S. Awad, “Ammonium methacrylate units polymer content and their effect on acyclovir colloidal nanoparticles properties and bioavailability in human volunteers,” Colloids and Surfaces B, vol. 75, no. 2, pp. 398–404, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Das, R. Banerjee, and J. Bellare, “Aspirin loaded albumin nanoparticles by coacervation: implications in drug delivery,” Trends in Biomaterials and Artificial Organs, vol. 18, no. 2, pp. 203–211, 2005. View at Google Scholar · View at Scopus
  20. N. Ma, L. Xu, Q. Wang et al., “Development and evaluation of new sustained-release floating microspheres,” International Journal of Pharmaceutics, vol. 358, no. 1-2, pp. 82–90, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. A. O. Kamel, G. A. S. Awad, A. S. Geneidi, and N. D. Mortada, “Preparation of intravenous stealthy acyclovir nanoparticles with increased mean residence time,” AAPS PharmSciTech, vol. 10, no. 4, pp. 1427–1436, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. N. Thirawong, J. Nunthanid, S. Puttipipatkhachorn, and P. Sriamornsak, “Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 67, no. 1, pp. 132–140, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. M. A. Schubert and C. C. Müller-Goymann, “Solvent injection as a new approach for manufacturing lipid nanoparticles—evaluation of the method and process parameters,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 55, no. 1, pp. 125–131, 2003. View at Publisher · View at Google Scholar · View at Scopus