Research Article
Screening of Most Effective Variables for Development of Gastroretentive Mucoadhesive Nanoparticles by Taguchi Design
Table 3
Preparation of nanoparticles on the basis of Taguchi screening design.
| | Formulation | Amount of gelatin (mg) | Amount of Glutaraldehyde (mL) | Amount of Pluronic F-68 (mg) | Acetone addition rate (mL/min) | pH | Stirring time (h) | Stirring speed (rpm) |
| | F1 | 200 | 0.1 | 50 | 1 | 2.0 | 1 | 200 | | F2 | 200 | 0.5 | 50 | 5 | 4.0 | 5 | 200 | | F3 | 1000 | 0.5 | 50 | 1 | 2.0 | 5 | 1000 | | F4 | 1000 | 0.1 | 50 | 5 | 4.0 | 1 | 1000 | | F5 | 1000 | 0.1 | 250 | 5 | 2.0 | 5 | 200 | | F6 | 1000 | 0.5 | 250 | 1 | 4.0 | 1 | 200 | | F7 | 200 | 0.5 | 250 | 5 | 2.0 | 1 | 1000 | | F8 | 200 | 0.1 | 250 | 1 | 4.0 | 5 | 1000 |
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Drug amount was kept constant at 200 mg.
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