Screening of Most Effective Variables for Development of Gastroretentive Mucoadhesive Nanoparticles by Taguchi Design

Table 4

Evaluation of formulations of Taguchi screening design.

Formulation	Particle Size (nm)	PDI	𝑄6^∗ (%)	𝑇^∗60% (h)	Entrapment efficiency* (%)	Drug loading* (%)	Mucoadhesion study* (g)
F1	165.3	0.906	15.00±0.26	26.8±0.351	20.26±1.98	39.72±1.03	6.021±0.094
F2	256.7	1.000	14.34±0.74	24.4±0.861	30.82±1.45	53.04±1.14	4.494±0.058
F3	478.3	0.832	34.93±0.86	21.2±0.984	15.70±2.16	47.25±2.01	11.02±0.846
F4	1610	0.360	7.31±0.64	37.6±0.654	51.69±2.48	55.07±2.48	8.347±0.989
F5	552.8	0.532	12.77±0.26	21.2±1.48	31.57±1.61	78.63±1.98	5.992±0.114
F6	345.9	1.000	7.59±1.29	37.2±2.03	49.30±3.04	80.49±2.85	5.029±0.0742
F7	319.3	0.656	11.89±2.35	24±0.987	83.12±2.45	59.04±1.64	3.959±0.056
F8	1300	0.809	15.42±0.35	19.2±0.494	67.79±1.47	71.23±1.03	5.029±0.081

∗Mean ± SD (𝑛=3); (𝑃<0.05).
𝑄₆ is amount of drug released in 6 h; 𝑇^∗_60% (h) is time required for 60% cumulative drug release.