Table of Contents
ISRN Pharmaceutics
Volume 2013 (2013), Article ID 348186, 10 pages
http://dx.doi.org/10.1155/2013/348186
Review Article

Pharmacosomes: An Emerging Novel Vesicular Drug Delivery System for Poorly Soluble Synthetic and Herbal Drugs

Nanomedical Research Centre, I.S.F. College of Pharmacy, Ferozepur G.T. Road Ghal Kalan, Moga, Punjab 142001, India

Received 2 July 2013; Accepted 1 August 2013

Academic Editors: F.-R. Chang, J. V. de Julián-Ortiz, J. Lee, and H. Mucke

Copyright © 2013 Archana Pandita and Pooja Sharma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the arena of solubility enhancement, several problems are encountered. A novel approach based on lipid drug delivery system has evolved, pharmacosomes. Pharmacosomes are colloidal, nanometric size micelles, vesicles or may be in the form of hexagonal assembly of colloidal drug dispersions attached covalently to the phospholipid. They act as befitting carrier for delivery of drugs quite precisely owing to their unique properties like small size, amphiphilicity, active drug loading, high entrapment efficiency, and stability. They help in controlled release of drug at the site of action as well as in reduction in cost of therapy, drug leakage and toxicity, increased bioavailability of poorly soluble drugs, and restorative effects. There has been advancement in the scope of this delivery system for a number of drugs used for inflammation, heart diseases, cancer, and protein delivery along with a large number of herbal drugs. Hence, pharmacosomes open new challenges and opportunities for improved novel vesicular drug delivery system.