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ISRN Biomarkers
Volume 2013 (2013), Article ID 353598, 8 pages
Research Article

CD133 Staining Detects Acute Kidney Injury and Differentiates Clear Cell Papillary Renal Cell Carcinoma from Other Renal Tumors

1Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI 48073, USA
2Department of Nephrology, William Beaumont Hospital, Royal Oak, MI 48073, USA
3Department of Urology, William Beaumont Hospital, Royal Oak, MI 48073, USA
4Research Institute, William Beaumont Hospital, Royal Oak, MI 48073, USA

Received 9 April 2013; Accepted 8 May 2013

Academic Editors: H.-L. Chan and R. H. Dammann

Copyright © 2013 John D. Schwartz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


CD133 has recently been characterized as a progenitor cell marker in the kidney. However, the expression of this marker has not been thoroughly investigated in kidney injury and variants of renal tumors for pathology practice. We quantified CD133 expression in kidney biopsies from patients with acute renal failure and compared staining intensity with serum creatinine levels. CD133 expression levels were also evaluated in several subtypes of renal neoplasms. Normal adult renal parenchyma showed CD133 expression in parietal epithelium and in less than 5% of the epithelial cells in proximal and distal nephron tubules. However, CD133 was diffusely upregulated in the injured proximal and distal tubular epithelium and the CD133 expression scores in renal tubules were significantly correlated with serum creatinine levels. Amongst the renal tumors, CD133 was diffusely expressed in clear cell papillary renal cell carcinoma but was only focally present in other types of renal tumors. In summary, CD133 is a useful marker to detect renal tubular injury and to differentiate clear cell papillary renal cell carcinoma from other tumor types.