Table of Contents
Retracted

At the request of the authors and the hospital, this article has been retracted. The data reported in the article were not reviewed by the Renal Transplant Unit of the Royal London Hospital before submission. The data is not a complete capture and as a result is not an accurate reflection of the effect of the intervention.

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References

  1. E. Giorgakis, A. Syed, and H. Gonzalez, “The impact of graft nephrectomy on subsequent transplants: multivariate analysis of risk factors for second graft loss and for multiple transplantations–A Single-Center Retrospective Study,” ISRN Transplantation, vol. 2013, Article ID 362571, 9 pages, 2013.
ISRN Transplantation
Volume 2013, Article ID 362571, 9 pages
http://dx.doi.org/10.5402/2013/362571
Research Article

The Impact of Graft Nephrectomy on Subsequent Transplants: Multivariate Analysis of Risk Factors for Second Graft Loss and for Multiple Transplantations–A Single-Center Retrospective Study

1Department of Transplantation, Royal London Hospital, London E1 1BB, UK
2Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK

Received 14 July 2013; Accepted 14 August 2013

Academic Editors: P. Ditonno, J. M. Rebibou, and H. Toz

Copyright © 2013 Emmanouil Giorgakis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. The management of a failed primary allograft remains unclear and the evidence of the effect of transplantectomy to future transplants conflicting. Aim of this study is to review the impact of failed primary graft nephrectomy on future transplants. Materials/Methods. Retrospective study of 101 patients retransplanted in a single institution. Median follow-up was 68 months. Patients were divided into two groups; G1 ( ) was the nephrectomy group; G2 ( ) was the graft in situ group. The patients’ and second graft survival were analysed with the Kaplan-Meier method. The patients’ and transplant characteristics were analyzed with student’s -test. The retransplant risk factors and the risk factors for multiple transplants were obtained via a logistic regression model. Results. The odds of second graft loss post-transplantectomy were high (OR = 5.24). Demographics, HLA mismatch and first graft rejection rates were similar among the two groups and did not affect the outcome. Transplantectomy accelerated the loss of a future failing graft. Multivariate analysis showed transplantectomy as independent risk factor for second allograft loss. Transplantectomy and younger age are significant independent risk factors for future multiple transplants. Conclusion. Transplantectomy of the failed primary graft is an independent risk factor for retransplant loss and for multiple renal transplants.