Table of Contents
ISRN Radiology
Volume 2013, Article ID 371028, 6 pages
Research Article

Assessment of Myocardial Contractile Function Using Global and Segmental Circumferential Strain following Intracoronary Stem Cell Infusion after Myocardial Infarction: MRI Feature Tracking Feasibility Study

1University of Cincinnati Hospital, Cincinnati, OH, USA
2Duke University School of Medicine, Durham, NC, USA
3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
4Emory University, Atlanta, GA, USA
5Amorcyte Inc., Hackensack, NJ, USA
6The Christ Hospital Heart and Vascular Center, Suite 138, 2123 Auburn Avenue, Cincinnati, OH 45219, USA
7University of Trieste, Trieste, Italy
8Center for Diagnosis Prevention and Telemedicine, John Paul II Hospital, Krakow, Poland

Received 3 July 2012; Accepted 3 September 2012

Academic Editors: G. Korosoglou and A. Melzer

Copyright © 2012 Sabha Bhatti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Magnetic resonance imaging (MRI) strain analysis is a sensitive method to assess myocardial function. Our objective was to define the feasibility of MRI circumferential strain ( ) analysis in assessing subtle changes in myocardial function following stem cell therapy. Methods and Results. Patients in the Amorcyte Phase I trial were randomly assigned to treatment with either autologous bone-marrow-derived stem cells infused into the infarct-related artery 5 to 11 days following primary PCI or control. MRI studies were obtained at baseline, 3, and 6 months. was measured in the short axis views at the base, mid and apical slices of the left ventricle (LV) for each patient (13 treatments and 10 controls). Mid-anterior LV improved between baseline − and 3 months − , . There were no significant changes in at 3 months and 6 months compared to baseline for other segments. There was excellent intraobserver and interobserver agreement for basal and mid circumferential strain. Conclusion. MRI segmental strain analysis is feasible in assessment of regional myocardial function following cell therapy with excellent intra- and inter-observer variability's. Using this method, a modest interval change in segmental was detected in treatment group.