Table of Contents
ISRN Stem Cells
Volume 2013, Article ID 372068, 6 pages
Review Article

Intestinal Stem Cells: Common Signal Pathways, Human Disease Correlation, and Implications for Therapies

Division of Hematology, Oncology, and Stem Cell Transplantation, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA

Received 25 October 2012; Accepted 15 November 2012

Academic Editors: A. Chapel, F. Fagioli, I. E. Hoefer, B. Machalinski, and B. Rogister

Copyright © 2013 Jignesh Dalal and Mohamed Radhi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Enterocytes originating from gastrointestinal stem cells are basic building blocks of villi and crypts in human intestine. Little is known about intestinal stem cells (ISCs), their interaction with niche, and key pathways in their regulation. In this paper, we have reviewed the characteristics of ISC, its interaction with niche, and the understanding of key signaling pathways like Wnt. A better understanding of all of this will help to better utilize novel therapies like mesenchymal stromal cells (MSCs), R-spondin1, and sulindac in various disorders like colon cancer, graft-versus-host disease, intestinal polyposis, and radiation-related bowel injuries.